流感灭活疫苗生产二次收获的研究  

RESEARCH ROR SECOND HARVEST OF INACTIVE INFLUFNZA VACCINE

作　　者：童东平[1] 王敏文[1] 张玉辉[1] 戴长河[1] 王艳波 颜淑芹[1] 

机构地区：[1]卫生部长春生物制品研究所,长春130062

出　　处：《吉林医学院学报》1997年第2期30-31,共2页

摘　　要：流行性感冒的重要性是可引起严重的发病率和死亡率。流感疫苗的研究迄今有５０多年的历史，是目前唯一可行的流感预防措施。流感灭活疫苗生产二次收获的研究是尽最大的可能将一次收获后的鸡胚尿囊腔中残存的尿液，病毒络合物的沉淀、细胞内未释放的病毒和病毒残片二次收获回来。It's over fifty yeare since the reseach for inactive influenza vaccine. The second harvest of influenza vaccine as colleeting survival virus; virus complex sediments; the virus unreleased in the cells and the virus fragments the first harvest as best as we can it could made a low cost . Good harvest and high virus titer.According to the permeabity, the high permeant fluid we added to the allantoic cavites of eggs than harvested. The vims titer was 1: 128 in 8 .5% Nace solution ; 1: 256 in M/7 .5 PBS controls ware 1: 100and 1: 128 separaely on a small scale test. The virus titer was over 1: 100 and harvest rate was 70% of the first harvest on a largr scale test. An ablut result shows that second harvest of inactive influenza vaccine in possibility.

关 键 词：流行性感冒 灭活疫苗 研制 二次收获 

分 类 号：R511.703[医药卫生—内科学] R392－33[医药卫生—临床医学]