脉搏波速度和踝臂指数与心血管危险因素的关系  

Correlation between pulse wave velocity and ankle-brachial index and cardiovascular risk factors in elderly patients

作　　者：李保应[1] 高海青[1] 李小利[2] 马亚兵[1] 刘远萍[1] 王敏[1] 

机构地区：[1]山东大学齐鲁医院老年病科,山东济南250012 [2]山东大学齐鲁医院临床药理研究所,山东济南250012

出　　处：《山东大学学报（医学版）》2007年第7期669-672,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:研究老年患者肱踝脉搏波速度(brachial-ankle pulse wave velocity,baPWV)和踝臂指数(an-kle-brachial index,ABI)与心血管危险因素的关系,并探讨baPWV和ABI在老年患者动脉硬化评估中的临床价值。方法:191例老年患者,男123例,女68例,平均年龄(71.73±7.95)岁,采用VP-1 000全自动动脉硬化测定仪分别检测患者血压、双侧baPWV和ABI。结果:老年患者中合并大动脉硬化者110例,总发病率为57.6%,与高血压病直接相关(P<0.05),其OR值为10.569,95%可信区间CI为4.748-23.527,而且与性别、年龄密切相关(P<0.05);合并外周血管疾病(peripheral arterial disease,PAD)者36例,发病率为18.8%,并且合并PAD与糖尿病直接有关(P<0.05),其OR值为4.383,95%可信区间CI为1.974-9.733(P<0.001)。结论:baPWV和ABI是两个相互独立的无创性、敏感性指标,两者相互结合可以有效地评估老年患者心血管危险因素的危害程度。Objective： To obtain reliable data on the epidemiology, co-morbidities and risk factor profile of large artery arteriosclerosis and peripheral arterial disease （PAD）, the clinical significance of brachial-ankle pulse wave velocity （baPWV） and ankle-brachial index （ABI） were evaluated as indicators of arteriosclerosis and PAD in aged patients. Methods： One hundred and ninety-one elderly patients （64.4% male, 71.73 years old in mean） were recruited for this study, baPWV and ABI were measured by the VP-1 000 automatic arteriosclerosis measurement system. Results： One hundred and ten elderly patients （57.6%） were found to have large artery arteriosclerosis. The risk of large artery arteriosclerosis in elderly patients became higher with an increase of age （OR = 1.060, 95% CI = 1.010-1. 113）. Gender （OR = 2.494, 95% CI= 1.067-5.825） and history of hypertension（OR= 10.569, 95% CI =4.748-23.527） were independently associated with high baPWV （P 〈0. 05）. Moreover, 36 elderly patients （18.8%） were found to have PAD. The risk of PAD in elderly patients was related to a history of diabetes mellitus（OR = 4.383, 95%CI = 1.974-9.733, P 〈 0.001）. Conclusion： BaPWV and ABI measurements are sensitive and independent indicators for evaluating the degree of arteriosclerosis and occlusion in the aged, which can effectively evaluate cardiovascular risk factors in elderly patients.

关 键 词：肱踝脉搏波速度 踝臂指数 动脉硬化 外周动脉疾病 

分 类 号：R543.5[医药卫生—心血管疾病]