IL-12、IFN-γ与复发性流产的相关性研究  

Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion

作　　者：王国华[1] 左常婷[1] 王立俊[1] 

机构地区：[1]山东大学山东省立医院妇产科,山东济南250021

出　　处：《山东大学学报（医学版）》2007年第7期702-704,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:测定复发性流产(RSA)患者血清IL-12、IFN-γ水平,探讨IL-12和IFN-γ与复发性流产发病的关系。方法:采用酶联免疫吸附法检测RSA患者30例(RSA组),血清IL-12、IFN-γ水平,并以正常早孕妇女25例(NEP组)及健康未孕妇女25例(NNP组)作为两个对照组。结果:RSA患者血清IL-12、IFN-γ水平显著高于正常早孕妇女及正常未孕妇女(P<0.05),且两者水平呈正相关性(r=0.580,P<0.01),正常早孕妇女血清IL-12、IFN-γ水平低于未孕妇女但无统计学意义(P>0.05)。复发性流产患者流产次数与血清IL-12和IFN-γ水平差异无显著性(P>0.05)。结论:IL-12和IFN-γ在复发性流产发生机制中起一定的作用。Objective： To explore the correlation between levels of interleukin-12 （IL-12） and interferon-γ （IFN-γ） and recurrent spontaneous abortion （RSA）. Methods： Thirty patients with RSA（ the RSA group）, twenty-five normal early pregnant women （the NEP group） and twenty-five normal non-pregnant women（ the NNP group） were enrolled in this study. The serum concentrations of IL-12 and IFN-γwere determined by enzyme-linked immunosorbant assay （ELISA）. Results： Levels of IL-12 and IFN-γ were significantly higher in the RSA group than in the other groups（P 〈 0.05） and there was a positive correlation between IL-12 and IFN-γ. Levels of IL-12 and IFN-γ were lower in the NEP group than in the NNP group, but there was no statistical difference（ P 〉0.05）. Conclusion： IL-12 and IFN-γ may play an important role in the occurrence of RSA.

关 键 词：流产 习惯性 白细胞介素-12 干扰素Ⅱ型 

分 类 号：R512.620.2[医药卫生—内科学]