大剂量甲氨蝶呤化疗致口腔黏膜炎的预防及护理  

Prevention and nursing care of high-dose methotrexate chemotherapy result in oral musositis

作　　者：肖玉兰 

机构地区：[1]山东省临沂市肿瘤医院,276001

出　　处：《护理实践与研究》2007年第4期35-36,共2页Nursing Practice and Research

摘　　要：目的:探讨大剂量甲氨蝶呤化疗致口腔黏膜炎的原因及护理对策。方法:通过回顾本科室48例患者进行120个疗程的大剂量甲氨蝶呤化疗,连续24h静脉滴注,滴注第36h开始给予四氢叶酸钙解救,同时予以水化及碱化尿液。结果:48例患者共进行120个疗程化疗,出现口腔黏膜炎20例,1～2级14例,3～4级6例。结论:只要严格执行化疗计划,严密观察病情,强化化疗护理,可以有效地预防和减轻黏膜炎发生。Objective：To discuss nursing measures of high - dose methotrexate chemotherapy result in oral musositis. Methods：48 patients with chemotherapy were given high - dose methotrexate for 120 periods of treatment, intravenous administration with 24 hours continuously, after 36h given leucovofin to save o Conclusion ： To observe disease closely and enhance chemotherapy nursing and adopt chemotherapy plan strictly can prevent and reduce oral mucositis effectly.

关 键 词：甲氨蝶呤 化疗 口腔黏膜炎 护理 

分 类 号：R473.73[医药卫生—护理学]