祛毒复欣口服液驱铅效果的试验研究  

Study on Lead-eliminating Function of Qudufuxin Oral Liquid

作　　者：魏萍 

机构地区：[1]河南省平顶山天宏焦化公司职工医院,河南平顶山467021

出　　处：《中国药业》2007年第15期17-18,共2页China Pharmaceuticals

摘　　要：目的观察祛毒复欣口服液对铅中毒大鼠体内铅含量、超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量的影响,从消除伤害和保护损伤两方面探讨中药制剂治疗慢性铅中毒的药理机制。方法将SD大鼠分组,饮用醋酸铅水溶液染毒造模,并给予祛毒复欣口服液治疗,以乙二胺四乙酸二钠钙为对照,试验结束时检测大鼠血、肝、骨等组织中铅含量,并检测血清SOD活性及肝脏MDA含量。结果祛毒复欣口服液能显著降低染毒大鼠血、骨及肝组织铅含量(P<0.05或P<0.01),升高染毒大鼠血清SOD活性和降低肝组织MDA含量(P<0.05和P<0.01)。结论祛毒复欣口服液对铅中毒模型大鼠具有明显排铅效果,同时能够减轻其铅中毒导致的氧化应激损伤,提示祛毒复欣口服液具有驱邪和扶正的双重效果。Objective To observe the effects of Qudufuxin oral liquid on expelling lead from the lead poisoning rats＇ tissues and affecting the activity of SOD, the content of MDA. The pharmacological mechanism of Chinese drugs preparation on treating chronic lead poisoning rats is discussed from both two aspects of driving away evil and strengthening body resistance. Methods SD rats were randomly divided into 5 groups. The model of lead poisoning rats were established by giving lead-contained drinking water （1% lead acetate）. The treated groups were fed Qudufuxin oral liquid and the positive control group was given EDTA- Na2Ca by stomach perfusion. At the end of the experiment the lead levels in blood, liver and bone and the activity of SOD in blood, the content of MDA in liver were determined. Results The lead levels of the groups receiving large and small doses of Qudufuxin oral liquid were apparently decreased compared with the control group （P 〈0.01 or P 〈0. 05）, meanwhile the activity of SOD was increased and the content of MDA was reduced significantly due to the function of Qudufuxin oral liquid. Conclusion The function of Qudufuxin oral liquid on expelling lead from the lead poisoning rats＇ tissues is certain. Meanwhile the damage of oxidative stress due to lead poisoning is relieved. According to the results, the effects of driving away evil and strengthening body resistance are characteristics of Qudufuxin oral liquid on lead- eliminating.

关 键 词：铅中毒 氧化损伤 祛毒复欣汤 驱铅 抗氧化 

分 类 号：R285.5[医药卫生—中药学]