有无吸烟史的晚期非小细胞肺癌4种化疗方案的临床比较  

Comparison of Clinical Researches on Four Chemotherapeutic Plans for Advanced Stage in Non Small Cell Lung Cancer with or without Smoking History

作　　者：何建萍[1] 易成[1] 鄢希[1] 任莉[1] 李潞[1] 罗德云[1] 侯梅[1] 毕锋[1] 谢名英[1] 

机构地区：[1]四川大学华西医院肿瘤化疗科,四川成都610041

出　　处：《中国药业》2007年第15期44-45,共2页China Pharmaceuticals

摘　　要：目的研究比较长春瑞滨、紫杉醇、多西紫杉醇、吉西他滨分别联合顺铂方案对有吸烟史和无吸烟史的晚期非小细胞肺癌的疗效及毒副作用。方法共277例患者,有吸烟史组185例,无吸烟史组92例。长春瑞滨25mg/m2,吉西他滨1000mg/m2,第1,8天使用;紫杉醇135mg/m2,多西紫杉醇75mg/m2,第1天使用;顺铂25mg/m2,第1,2,3天使用。21d或28d为1个周期。结果有吸烟史组NP方案(47例)有效率为34.0%,PP方案(57例)有效率为35.1%,DP方案(35例)有效率为37.1%,GP方案(46例)有效率为30.4%,总有效率为34.1%;无吸烟史组NP方案(27例)有效率为33.3%,PP方案(23例)有效率为30.4%,DP方案(24例)有效率为37.5%,GP方案(18例)有效率为33.3%,总有效率为33.7%。两组均有血液学毒性和非血液学毒性。结论有吸烟史和无吸烟史的晚期非小细胞肺癌患者化疗疗效相近。Objective To compare the therapeutic effect and adverse reactions of 4 chemotherapeutic plans, combining cisplatin （PR） with vinorbebine （VP）, paclitaxel （PP）, docetaxel （DP） or emcitabine （GP）, for advanced stage in non- small- cell lung cancer with or without smoking history. Methods The chemotherapeutic plans included： NP, PP, DP and GP. There were 185 cases （NP 47, PP 57,DP 35,GP 46） in the smoking group and 92 cases （NP 27, PP 23,DP 24,GP 18） in the non-smoking group. To use VP 25 mg/m^2, GP 1 000 mg/m^2 on 1st, 8th d; PP 135 mg/m^2, DP 75 mg/m^2 on 1st d; PR 25 mg/mz on 1st, 2nd, 3rd d. 21 d or 28 d were as one cycle of treatment. Results The therapeutic effective rates of the smoking group were as follows： NP34.0% ,PP35. 1% ,DP37. 1% ,GP30.4% ,the total effective rate was 34. 1% ; the therapeutic effective rates of the non - smoking group were as follows： NP 33.3% , PP 30. 4% , DP 37.5% , GP 33.3% , the total effective rate was 33.3%. Both groups displayed hematologic and non-hematologic toxicity. Conclusion The therapeutic effects of smoking groups and non- smoking group are approximate.

关 键 词：非小细胞肺癌 吸烟史 无吸烟史 联合化疗 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]