吲哚胺2,3-双加氧酶在新月体肾炎肾组织中的表达变化  

Expression of indoleamine 2,3-dioxygenase in renal tissues of crescent nephritis

作　　者：侯卫平[1] 袁发焕[1] 赵红艳[2] 

机构地区：[1]第三军医大学新桥医院全军肾脏病中心,重庆市肾病研究所,重庆400037 [2]第三军医大学新桥医院病理科,重庆400037

出　　处：《第三军医大学学报》2007年第15期1491-1493,共3页Journal of Third Military Medical University

基　　金：重庆市自然科学基金(2006BB5055)~~

摘　　要：目的检测新月体肾炎患者肾组织中吲哚胺2,3-双加氧酶(indoleamine2,3-dioxygenase,IDO)的表达情况及其与肾组织浸润炎细胞的增殖和肾小管-间质病理损害程度之间的关系。方法采用免疫组织化学染色法检测正常肾组织和新月体肾炎患者肾组织IDO的表达情况,并进一步分析其表达与肾间质浸润PCNA阳性炎细胞数及肾小管-间质病理损害程度之间的相关关系。结果正常肾组织未检测到IDO表达,而在新月体肾炎患者肾小管上皮细胞IDO的表达显著上调,并且新月体肾炎肾小管上皮细胞IDO的表达强度与肾小管-间质PCNA阳性浸润细胞数及肾小管-间质病理损害程度显著负相关。结论IDO在新月体肾炎肾小管上皮细胞中高表达并与肾小管-间质炎细胞增殖及小管-间质病理损害相关,提示IDO可能通过抑制炎细胞增殖活性参与新月体肾炎肾小管-间质病理损害过程。Objective To investigate the expression of indoleamine 2,3-dioxygenase （IDO） in renal tissues of crescent nephritis and its correlation with cell proliferation and pathologic tubulointerstitial lesion. Methods Immunohistochemistry was used to detect IDO expression in renal tissues of crescent nephritis and normal renal tissues. The correlation between IDO expression and the number of proliferating cell nuclear antigen （ PCNA） positive cells or pathologic tubulointerstitial lesion were analyzed. Results IDO expression was found in the renal tubular epithelial cells of crescent nephritis, while that in the normal renal tissues was negative by immunohistochemical staining. The expression of IDO protein in tubular epithelial ceils showed a significantly negative correlation with the number of PCNA positive cells or tubulointerstitial lesion of crescent nephritis. Conclusion IDO may participate in the pathogenesis of crescent nephritis by inhibiting the cell proliferation.

关 键 词：新月体肾炎 吲哚胺2 3-双加氧酶 核增殖抗原 

分 类 号：R345[医药卫生—基础医学] R36