救心复脉注射液对大鼠的长期毒性试验  

Long-term Toxicity of Jiuxin Fumai Injection in Rats

作　　者：李灿[1] 黄道生[1] 钟炳武[1] 杨剑刚[1] 孙兆泉[2] 刘礼意[2] 

机构地区：[1]中南大学湘雅二医院中医科,长沙410011 [2]湖南省中医药研究院中药所,长沙410013

出　　处：《中药新药与临床药理》2007年第4期296-298,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金："八五"国家科技攻关项目(85919030201)

摘　　要：目的观察救心复脉注射液对大鼠的长期毒性,以了解临床用药的安全性。方法救心复脉注射液分高、中、低剂量组(分别为20,10,5g·kg-1)给大鼠肌注,每天1次,并设生理盐水对照组,连续用药2周,停药后恢复期2周,观察救心复脉注射液对大鼠的毒性反应及其程度。结果连续用药2周,大鼠全部存活。高、中剂量组部分大鼠给药时出现呕吐、易激动;高剂量组大鼠血糖升高、胸腺系数下降、肝细胞有轻中度浊肿。经2周恢复期,上述现象均消失。低剂量组大鼠未见明显毒性反应。结论救心复脉注射液长期肌注给药,高剂量对大鼠有一定的毒性反应,5g·kg-1·d-1以下大鼠肌注给药是比较安全的剂量。Objective To observe the long -term toxicity of Jiuxin Fumai Injection and to investigate the safety of clinical medication. Methods The rats were given intramuscular injection with Jiuxin Fumai Injection in large, medium, small dosage （respectively 20, 10, 5g·kg^-1） every clay for two weeks, and normal saline group served as the normal control. Two weeks after drug withdrawal, the toxic reaction in rats was observed. Results After two - week continuous administration, all the animals were alive. Some animals were vomiting and getting excited when administered the large dosage and medium dosage injection. The blood sugar elevated, the thoracic gland coefficient lowered, the hepatic cells were cloudily swollen in the animals of large dosage group. Two weeks after drug withdrawal, the above phenomenon vanished. There was no obvious toxic reaction in the small - dosage injection group. Conclusion Long - term administration of Jiuxin Fumai Injection in large dosage shows certain toxic reaction in rats. The safe dosage for intramuscular administration is less than 5 g·kg^-1·d^-1.

关 键 词：救心复脉注射液 对羟福林 N-甲基酪胺 枳实 大鼠 长期毒性 

分 类 号：R285.5[医药卫生—中药学]