大鼠脑内AV3V心房肽降压区和A-Ⅱ升压系统功能联系  

Functional Connection between AV3V-atriopeptin Depressor Area and Angiotensin Ⅱ Pressor System in Rat Brain

作　　者：李耀华[1] 顾蕴辉[2] 

机构地区：[1]云南省大理市大理学院生理学与病理生理学教研室,671000 [2]北京大学医学部生理系

出　　处：《医学研究杂志》2007年第8期26-29,共4页Journal of Medical Research

基　　金：云南省教育厅科学研究基金项目(02ZY136)

摘　　要：目的为了验证ANP能神经是否从第3脑室前腹侧区(AV3A)投射到血管紧张素Ⅱ(AⅡ)升压系统。方法用脑内微量注射药物,观察动脉血压和心率变化的方法。结果①心房钠尿肽(APeⅢ)分别注入SFO,LH/PF,NPV和RVL后,引起血压下降;②在SFO,双侧的LH/PF,NPV和RVL预注射A71915(一种心房钠尿肽Ⅲ的抑制剂),产生谷氨酸兴奋AV3V的相反效应。结论刺激AV3V的心房钠尿肽能神经,可分别在LH/PF-SFO-NPV-RVL的血管紧张素Ⅱ(AⅡ)升压系统引起降压效应。A71915注入以上核团可反转AV3V的降压效应。Objective The purpose of the study was to examine whether ANP ergic projections from the AV3V could act upon nuclei involved in the A Ⅱ pressor system. Methods lntrahrain microinjection of drugs observation of changes in arterial pressure and heart rate were used. Results （1）atriopeptin Ⅲ - injection into either the LH/PF, SFO, NPV or RVL induced a depressor response. （2）preinjection of A71915 （an atriopeptin Ⅲ antagonist） into either bilateral LH/PF, SFO, bilateral NPV or RVL reversed the depressor response of the AV3V to glutamate. Conclusions The results indicate that excitation of atriopeptinergic neurons in the AV3V produces an inhibitory effect on each nucleus in the LH/PF - SFO - NPV - RVL AⅡ pressor system. A71915 injection into any one of these nuclei can reverse the AV3V depressor response.

关 键 词：脑 第3脑室前腹侧区 心房钠尿肽 降压反应 血管紧张素Ⅱ 

分 类 号：R331[医药卫生—人体生理学]