通心络胶囊对原发性肥厚型心肌病左室功能影响的观察  

Effects of Tongxinluo capsules(通心络胶囊) on left ventricular function of patients with primary hypertrophic cardiomyopathy

作　　者：苏晓燕[1] 吕维红[1] 张弈[2] 梁艳敏[1] 徐敏[1] 

机构地区：[1]河北沧州市人民医院心内科,河北沧州061000 [2]河北沧州中西医结合医院心内科

出　　处：《中国中西医结合急救杂志》2007年第4期231-232,共2页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的:观察通心络胶囊对原发性肥厚型心肌病(HCM)左室功能的影响。方法:18例原发性HCM患者治疗前停用一般治疗药物,然后给予通心络胶囊,每次3粒,饭后服用,每日3次,连服4周。用药前及用药后使用彩色多普勒超声和心电图检查测定左室收缩和舒张功能。结果:与用药前比较,用药后患者的左室射血分数(LVEF)、心排血量(CO)、左室短轴收缩率(ΔFS)、心房充盈分数(AFF)均无明显改变,差异均无显著性(P均>0.05);等容舒张时间(IRT)、慢充盈分数(SFF)均显著下降,二尖瓣前叶斜率、平均快速充盈速度(M RFV)、快充盈分数(RFF)及标准化快充盈(RFR/EDV)均显著升高,差异均有显著性(P均<0.01)。用药后心率显著减慢(P<0.05),但动脉收缩压(SBP)和左室收缩末期内径(LVESD)均无明显改变(P均>0.05)。结论:通心络胶囊可显著改善原发性HCM患者的左室收缩和舒张动能,对治疗原发性HCM具有较好疗效。Objective： To observe the effects of Tongxinluo capsule （通心络胶囊） on left ventricular function of patients with primary hypertrophic cardiomyopathy （HCM）. Methods： Eighteen primary HCM patients withdrew their usual medicine therapy before treatment, and then Tongxinluo capsules （3 capsules after a meal, three times a day for 4 weeks） were orally given to them. Left ventricular systolic function and diastolic function were measured by using color Doppler echocardiography and electrocardiogram （ECG） before and after treatment. Results ： After treatment, the patients＇ left ventricular ejection fraction （LVEF）, cardiac output （CO）, systolic rate of minor axis （AFS） and atrial filling fraction （AFF） were not changed significantly compared with those before treatment （all P〉0. 05）. The levels of isovolumic relaxation time （IRT） and slow filling fraction （SFF） decreased significantly. The mitral value slope, mean rapid filling velocity （MRFV）, rapid filling fraction （RFF） and rapid filling rate/end diastolic velocity （RFR/EDV） were all significantly increased, the differences were significant （all P〈0. 01）. Heart rate was remarkably reduced after treatment （P〈0.05）, but the changes of artery systolic blood pressure （SBP） and left ventriclular end- systolic diamension （LVESD） were not remarkably changed （both P〉0. 05）. Conclusion： Tongxinluo capsules can improve the left ventricular systolic function and diastolic function, and have good therapeutic effects on treatment for primary HCM.

关 键 词：通心络胶囊 心肌病 肥厚型 原发性 左室功能 

分 类 号：R259[医药卫生—中西医结合]