伽玛刀放射外科治疗垂体大腺瘤临床研究  

Treatment of Large Pituitary Adenoma with Gamma Knife

作　　者：潘绵顺[1] 王鹏[1] 朱世友[1] 许玉华[1] 

机构地区：[1]安徽省合肥市合肥脑科医院,安徽合肥230022

出　　处：《中国神经肿瘤杂志》2007年第2期99-102,共4页Chinese Journal of Neuro-Oncology

基　　金：卫生部科研基金(WKJ2005-3-006)

摘　　要：背景与目的:垂体大腺瘤多数以手术治疗为主,但有部分患者不接受手术,是否可行伽玛刀治疗?本文回顾性分析96例垂体大腺瘤的伽玛刀放射外科临床资料,探讨其治疗策略。方法:1997年到2003年,本院行伽玛刀治疗的垂体瘤302例,其中96例为垂体大腺瘤,50%等剂量曲线包绕肿瘤体积1/2或2/3,肿瘤基底部周边剂量14～27Gy,中心剂量30～40Gy,视通路控制在8～10Gy以下。结果:伽玛刀放射外科治疗后随访平均34个月,临床症状、MRI检查肿瘤大小及形态的改变、内分泌检查相关激素的变化、视力视野均得到显著改善。结论:伽玛刀放射外科采用剂量-体积分割治疗垂体大腺瘤是一个可以选择的治疗手段。BACKGROUND ＆ OBJECTIVE： Most of large pituitary adenomas were treated by surgery. This study is to evaluate the role of gamma knife in the treatment of large pituitary adenoma. METHODS： From 1997 to 2003,96 patients with large pituitary adenoma were treated with Gamma knife in Hefei Brain Hospital. The broad coverage of the target volume was 1/2 to 2/3 within the 50% isodose curve. The marginal dose for the tumor base was 14 to 27Gy,and the maximum dose was from 30 to 40 Gy. The maximum dose to the visual path-ways below 8~10Gy. RESULTS： After an average follow-up period of 34 months,the clinical symptoms,tumor volumes,serum endocrinological hormones levels,vision aeuities and vision field were improved greatly. CONCLUSIONS： Dose volume-staged treatment of large pituitary adenoma with gamma knife is also an effective treatment strategy.

关 键 词：立体定向放射外科 伽玛刀放射外科 脑肿瘤/ 垂体巨腺瘤 

分 类 号：R811.5[医药卫生—放射医学]