系统性红斑狼疮患者血清IL-10、IL-12和sFas水平及其临床意义  

Clinical Significance of Serum Levels of IL-10,IL-12 and sFas in Patients with SLE

作　　者：刘瑞玉[1] 张舜玲[2] 钟伟强[2] 巫远忠[1] 余相[1] 曹海燕[1] 陈江涛[1] 黄铁锋[1] 胡俊[2] 

机构地区：[1]广东省惠州市中心人民医院检验中心,惠州516001 [2]广东省惠州市中心人民医院内科,惠州516001

出　　处：《热带医学杂志》2007年第7期669-670,共2页Journal of Tropical Medicine

摘　　要：目的探讨系统性红斑狼疮(SLE)患者血清白细胞介素10(IL-10)、白细胞介素12(IL-12)和可溶性Fas(sFas)水平及其临床意义。方法采用酶联免疫夹心(ELISA)法检测22例SLE患者和20例正常人血清IL-10、IL-12和sFas水平。结果与正常对照组比较,SLE患者IL-10和sFas水平明显升高(P<0.01);IL-12水平有下降趋势,但差异无统计学意义(P>0.05)。结论IL-10、IL-12和sFas与SLE免疫发病机制密切相关。Objective To study the serum levels of interleukin 10 （IL-10）, interleukin 12 （IL-12）, soluble Fas （sFas） in patients with systemic lupus erythematosus （SLE） and their clinical significance. Methods Enzyme linked immunosorbent assay （ELISA） was used to detect IL-10, IL-12 and sFas in serums of 22 patients with SLE and 20 normal control subjects. Results The serum levels of IL-10 and sFas were significantly higher in patients with SLE than the control subjects （P〈0.01）. The level of IL-12 in SLE patients was lower than the control subjects, but the differences were not significant （P 〉 0.05）. Conclusion The elevated levels of serum IL-10 and sFas are correlated with the pathogenesis of SLE.

关 键 词：系统性红斑狼疮 白细胞介素10 白细胞介素12 可溶性FAS 

分 类 号：R593.241[医药卫生—内科学]