核因子kappaB基因多态性与2型糖尿病易感性相关的研究  

The association of nuclear factor kappa B (NF-κB) polymorphism with susceptibility to type 2 diabetes

作　　者：赵琳[1] 邹大进[1] 张征[1] 

机构地区：[1]第二军医大学附属长海医院内分泌科,上海200433

出　　处：《中国糖尿病杂志》2007年第7期408-410,共3页Chinese Journal of Diabetes

基　　金：国家"十五"攻关项目糖尿病病因和并发症研究基金(2001BA702B01)

摘　　要：目的探讨核因子kappaB基因多态性与2型糖尿病(T2DM)易感性的相关性。方法PCR荧光法分析T2DM组(160例)和正常健康对照组(Con,82例)NF-κB的(CA)重复序列的多态性。结果A4(124bp)等位基因的频率在Con组中明显高于T2DM组;A8(132bp)等位基因频率在T2DM组中明显高于Con组。结论NF-κB1基因在T2DM易感性上可能起到重要作用:等位基因A8携带者比A4携带者更容易患T2DM。Objective To explore the relationship of the CA-dinucleotide repeated sequence of microsatellite of the NF-κB gene with pathogenesis of type 2 diabetes mellitus （DM）. Methods By using PCR-fluorescence we examined CA-dinucleotide repeated sequence of microsatellite on the NF-κB gene in 186 patients with T2DM and 82 healthy subjects as control （Con）. Results There was a increased frequency of allele A4（124bp） in Con （28.66%） compared with that in T2DM（1.88%）（P〈0.01）. There was a increased frequency of allele A8 in T2DM （31.56%） compared with that in the Con（11.59%）（P〈0.01）. Conclusions The NF-κB gene may play a role in the susceptibility to type 2 diabetes, and individuals with the A2 allele may be more likely to develop diabetes as compared with the A14 allele.

关 键 词：NF-ΚB 糖尿病 2型 糖尿病肾病 多态性 基因频率 

分 类 号：R587.1[医药卫生—内分泌]