主动免疫治疗原因不明习惯性流产后细胞免疫功能的变化  

The Changes of T Lymphocytes Sub-types in Unexplained Recurrent Spontaneous Abortion Women after Active Immunotherapy.

作　　者：齐瑞莹[1] 侯灵彤[1] 

机构地区：[1]华北煤炭医学院附属医院妇产科,河北唐山063000

出　　处：《中国妇幼保健》2007年第21期2958-2959,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨原因不明习惯性流产(URSA)患者外周血T淋巴细胞亚群在主动免疫治疗前后的变化。`方法:用流式细胞仪测定并比较经主动免疫治疗前后的32例URSA患者外周血CD3+、CD4+、CD8+细胞亚群百分率及CD4+/CD8+比值;同时选择30例正常早孕妇女作为对照。结果:与对照组比较,URSA患者外周血中CD4+细胞百分率及CD4+/CD8+比值升高,CD8+细胞百分率降低(均P<0.01),而两组CD3+细胞百分率无差异。主动免疫治疗后CD3+细胞无变化,CD4+细胞、CD4+/CD8+比值较治疗前明显下降;CD8+细胞则明显升高(均P<0.01)。结论:CD4+细胞百分率升高、CD8+细胞百分率降低与UR-SA发生有关;主动免疫治疗可降低CD4+细胞百分率,提高CD8+细胞百分率,有利于妊娠发展。Objective： To investigate the changes of T lymphocytes sub - types in unexplained recurrent spontaneous abortion （URSA） women before and after active immunotherapy. Methods： Flow cytometry was used to measure T lymphocytes sub -types of 32 URSA women before and after active immunotherapy and 30 normal early pregnant women were taken as control. Results： Compared with control group, CD4^＋ cells and CD4^＋/CD8^＋ ratio increased significantly in URSA women, but CD8^＋ cells decreased significantly, there were no significant changes in CD8^＋ cells between two groups. After active immunotherapy, CD4^＋ cells and CD4^＋/CD8^＋ ratio dropped, but CD8^＋ cells increased greatly in URSA women, there were still no significant changes in CD3^＋ cells. Conclusion： The occurrence of URSA might be associated with proliferation of the CD4^＋ cells and decrease of the CD8^＋ cells. Markedly dropped CD4^＋ cells and increased CD8^＋ cells in URSA women after active immunotherapy is in favor of conception.

关 键 词：习惯性流产 T淋巴细胞亚群 主动免疫 治疗 

分 类 号：R714.21[医药卫生—妇产科学]