新疆汉族男性高尿酸血症与代谢综合征相关性研究  

The correlated study of hyperuricemia and metabolic syndromes among males of Han ethnicity in Xinjiang

作　　者：姚华[1] 孙玉萍[2] 李清[3] 姚文海[3] 王秋云[3] 胡静[3] 古丽巴哈.阿不都热合曼 妥玲[3] 江艳[4] 

机构地区：[1]新疆医科大学中医学院,新疆乌鲁木齐830000 [2]新疆医科大学基础医学院病原学教研室,新疆乌鲁木齐830000 [3]新疆医科大学附属中医医院,新疆乌鲁木齐830000 [4]新疆医科大学公共卫生学院,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2007年第6期535-538,共4页Journal of Xinjiang Medical University

基　　金：教育部高等学校博士点科研基金项目(20060760002);新疆高校创新群体科研基金(XJEDV200G09);新疆维吾尔自治区劳动卫生与环境卫生学重点学科建设基金

摘　　要：目的:了解新疆汉族男性高尿酸血症与代谢综合征的相关性。方法:对1469例汉族男性体检者的身高、体重、腰围、臀围、收缩压(SBP)、舒张压(DBP)进行测量,并检测其血液生化指标,包括血尿酸(SUA)、空腹血糖(FBG)、尿素氮(BUN)、肌酐(SCR)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)。结果:本研究人群中高尿酸血症检出率为39.1%,代谢综合征的检出率为18%。高尿酸组体质指数(BMI)、腰臀比(WHR)、SBP、DBP、FBS、TG、TC、LDL-C与代谢综合征的相关指标均高于正常组,且均与血尿酸密切相关;正常组和高尿酸组相比,肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症检出率差异均有统计学意义(P<0.05),高尿酸血症组发生肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症的危险分别是尿酸正常者的3.097、2.633、2.226、2.094、3.058倍(P<0.05)。结论:代谢综合征相关危险因子如肥胖、腹部脂肪堆积、高血糖、高血压、高甘油三酯血症等是新疆汉族男性发生高尿酸血症的危险因素,应加强对高尿酸血症和代谢综合征的健康教育。Objectives： To investigate the relationship between serum uric acid （UA） and metabolic syndrome （MS） among males of Han ethnicity in Xinjiang. Methods： The blood samples were collected from January to May 2006 in Urumqi, It included 1 496 subjects. These subjects people were analyzed for Serum uric acid（SUA）, the fasting blood sugar （FBS）, serum triglyceride（ TG）, serum total cholesterol（ TC）, serum high density lipoprotein （HDL-C）, and serum low density lipoprotein （LDL-C） as well as biochemistry targets. Data were analyzed using the Pearson chi-square test and Mann-Whitney Test and the Mantel-Haenszel test for linear trend respectively. Results： The prevalence of complete MS and hyperuricemia in the present study were 18% and 39. 1%. Blood ressure, FBS ,bodymass index （BMI）,waist/hip ratio, TG,TC,LDL-C were significantly higher in peoples with hyperuricemia than in normal persons and these factors were strongly related to serum uric acid too, The components of metabolic syndrome such as fat, hyperglycemia, hypertension, dyslipidemia were showed closely correlated with SUA. The Odds ratios of these metabolic diseases in hyperuricemia group were 3. 097-times, 2. 633-times, 2. 226-times, 3. 058-times to SUA normal group respectively. They all had positive correlations. Conclusions： Hyperuricemia is closely linked to the various components of the metabolic syndrome, more emphasis should be put on the evolving control and prevalence of hyperuricemia and metabolic syndrome among males of Han ethnicity in Xinjiang.

关 键 词：高尿酸血症 代谢综合征 相关性 

分 类 号：R696[医药卫生—泌尿科学] R58[医药卫生—外科学]