解偶联蛋白2启动子-866G/A多态性与和田维吾尔族长寿老人体质指数的关系  

Investigation into the correlation of the common-866 G/A polymorphism in the promoter of uncoupling protein 2 and body mass index of Uygur longevities in Hetian

作　　者：孙凌[1] 许群[2] 程祖亨[1] 邱长春[2] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830054 [2]中国医学科学院基础医学研究所医学分子生物学国家重点实验室,北京100005

出　　处：《新疆医科大学学报》2007年第6期557-559,562,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30160089);美国中华医学基金(CMB96-657)资助项目

摘　　要：目的:探讨解偶联蛋白2(UCP2)基因启动子区-866G/A多态性与和田维吾尔族长寿老人体质指数(BMI)之间的关系。方法:以和田地区59名90岁以上的维吾尔族长寿个体为研究对象,测定身高、体重等相关指标,并计算BMI。采用PCR-限制长度片段多态性(PCR-RFLP)和PCR-直接测序法(PCR-Sequencing)对UCP2基因-866G/A碱基多态性进行分型,应用方差分析方法检测不同基因型之间BMI的差异。结果:统计分析显示,启动子-866变异与长寿者BMI相关,A/A基因型BMI最高,而G/G基因型最低,随着A等位基因增加,BMI增加。结论:UCP2基因启动子-866G/A多态性与和田长寿者BMI相关,A/A基因型携带者BMI增高。Objective： To investigate the relation between the polymorphism of promoter region -866 G/A in the Uncoupling protein-2（UCP2） gene and the body mass index（BMI） of Uygur longevities in Hetian. Methods： Fifty nine healthy individuals over 90 years old were recruited. Their height and weight were measured, and BMI were calculated. The -866 G/A polymorphism were genotyped by PCR-RFLP and PCR-Sequencing. The correlation between genotypes and BMI were evaluated by ANOVA. Results： -866 G/A variation was related to BMI in the longevities. The BMI was highest in the A/A genotype carriers, and lowest in the G/G genotype carriers. Moreover, the BMI increased along with the increase of A alleles. Conclusion： We observed the correlation between the polymorphism -866G/A of UCP2 gene and BMI in longevities. And the BMI in A/A genotype carriers increased.

关 键 词：UCP2基因 启动子 多态性 体质指数 

分 类 号：R562.25[医药卫生—呼吸系统]