他汀类药物对急性冠状动脉综合征患者血清妊娠相关性血浆蛋白-A的影响  

Effect of serum pregnancy-associated plasma-A level in patients with acute coronary syndrome treated with TATIN

作　　者：潘伟 韩玉龙[2] 方长庚 张小勇 刘学路 马敏 章体玲 

机构地区：[1]广东省佛山市三水人民医院心血管内科,528100 [2]安徽医科大学第四临床学院心血管内科 [3]云南省心血管病研究所冠心病基础研究室

出　　处：《中国医药》2007年第9期524-526,共3页China Medicine

摘　　要：目的探讨应用他汀类药物后急性冠状动脉综合征(ACS)患者妊娠相关性血浆蛋白-A (PAPP-A)水平的变化。方法应用双抗夹心酶联免疫吸附法(EUSA)分别测定40例ACS应用他汀类药物前后、20例稳定型心绞痛(SA)及20例非冠心病患者血清PAPP-A水平。结果ACS患者血清PAPP-A浓度均明显高于SA组和非冠心病组患者。应用他汀类药物后ACS患者血清PAPP-A水平降低(均P<0.01)。结论PAPP-A浓度在ACS患者血中明显升高,为ACS易损斑块新的血清标志物。Objective To investigate changes of the serum pregnancy-associated plasma protein-A （ PAPP- A ） level in the patients with acute coronary syndrome （ACS） after treatment with TATIN. Methods The serum PAPP-A was detected by ELISA in 40 ACS patients and 20 stable angina patients and 20 non-CAD patients. Results PAPP-A levels were significantly higher in patients with ACS than in patients with stable angina and non-CHD and were higher in patients with ACS after taking TATIN （ P 〈 0.01 ）. CondusIon PAPP-A levels are elevated in ACS and it is a new candidate marker of ACS which can reflect the instability of coronary atheroselerotie plaque.

关 键 词：急性冠状动脉综合征 妊娠相关性蛋白-A 易损斑块 

分 类 号：R541.4[医药卫生—心血管疾病]