多因素干预对首发2型糖尿病患者颈总动脉内中膜厚度的影响  

Effects of the multifactorial intervention on common carotid intima-media thickness of first episode type 2 diabetics

作　　者：刘玉华[1] 黄姣平[1] 黄秀娟[1] 赖小惠[1] 陈伟坤[1] 熊斌[1] 黄灼伦[1] 

机构地区：[1]东莞市人民医院ICU病房,广东东莞523018

出　　处：《临床心身疾病杂志》2007年第4期292-294,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨多因素强化干预对首发2型糖尿病患者颈总动脉内、中膜厚度增厚的影响。方法对90例首发2型糖尿病患者进行多因素强化干预治疗,以干预前后颈总动脉内、中膜厚度差值≥0.02mm为界限,将患者分为增厚组24例及非增厚组66例,比较两组代谢指标及其与颈总动脉内、中膜增厚的关系。结果增厚组吸烟、饮酒、高血脂、高血压史的比例及平均年龄均显著高于非增厚组(P<0.05);强化干预治疗1a末,两组空腹血浆葡萄糖、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、收缩压、舒张压、体重指数、24h尿微量白蛋白等水平均显著低于干预前(P<0.05或0.01)。Logistic回归分析,颈总动脉内、中膜增厚与年龄、糖化血红蛋白、高敏C-反应蛋白等因素密切相关。结论对首发2型糖尿病患者综合强化干预时间越早,血糖下降越显著,颈总动脉内、中膜增厚进展越慢。Objective To explore the effects of multifactorial strengthening intervention on common carotid artery intima-media thickness （CCAIMT） of first-episode type 2 diabetics Methods 90 first-episode type 2 diabetics received the multifactorial strengthening intervention, were divided into thickening（n=24） and non-thickening group（n=66） according to the limit i. e. thickness difference≥0.02 mm between pre-and post-intervention, and intergroup comparisons of metabolism indices and their relationships with the CCAIMT were conducted. Results Ratios of smoking, drinking wine, hyperlipemia and hypertension history as well as mean age were significantly higher in the thickening than in the non-thickening group（P〈0.05） ; after one year intervention, such factors＇ levels as fasting plasma glucose, glycosylated hemoglobin, TG, TC, C-HDL, C-LDL, SBP, DBP, BMI and 24 hour UR trace AL Were significantly lower compared with pre-intervention（P〈0.05 or 0.01）. Logistic regression analyses showed that CCAIMT was close related to age, glycosylated hemoglobin , high-sensitive C-reactive protein. Conclusion The earlier comprehend strenthening intervention were conducted in first-episode type 2 diabetics, the more signnificantly decreased the blood sugar, and the slower progressed the common carotid artery intima-media thickness.

关 键 词：2型糖尿病 颈总动脉内 中膜 糖化血红蛋白 高敏C-反应蛋白 多因素干预 

分 类 号：R587.1[医药卫生—内分泌]