The progress of olfactory transduction and biomimetic olfactory-based biosensors  

作　　者：WU ChunSheng WANG LiJiang ZHOU Jun ZHAO LuHang WANG Ping 

机构地区：[1]Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China [2]Department of Biochemistry and Molecular Biology, Medical College of Zhejiang University, Hangzhou 310058, China

出　　处：《Chinese Science Bulletin》2007年第14期1886-1896,共11页

基　　金：National Natural Science Foundation of China (Grant No. 30627002);Foundation of Zhejiang Province for Outstanding Talents (Grant No. R205502)

摘　　要：Olfaction is a very important sensation for all animals. Recently great progress has been made in the research of olfactory transduction. Especially the novel finding of the gene superfamily encoding olfactory receptors has led to rapid advances in olfactory transduction. These advances also promoted the research of biomimetic olfactory-based biosensors and some obvious achievements have been obtained due to their potential commercial prospects and promising industrial applications. This paper briefly introduces the biological basis of olfaction, summarizes the progress of olfactory signal transduction in the olfactory neuron, the olfactory bulb and the olfactory cortex, outlines the latest devel- opments and applications of biomimetic olfactory-based biosensors. Finally, the olfactory biosensor based on light addressable potentiometric sensor (LAPS) is addressed in detail based on our recent work and the research trends of olfactory biosensors in future are discussed.Olfaction is a very important sensation for all animals. Recently great progress has been made in the research of olfactory transduction. Especially the novel finding of the gene superfamily encoding olfactory receptors has led to rapid advances in olfactory transduction. These advances also promoted the research of biomimetic olfactory-based biosensors and some obvious achievements have been obtained due to their potential commercial prospects and promising industrial applications. This paper briefly introduces the biological basis of olfaction, summarizes the progress of olfactory signal transduction in the olfactory neuron, the olfactory bulb and the olfactory cortex, outlines the latest developments and applications of biomimetic olfactory-based biosensors. Finally, the olfactory biosensor based on light addressable potentiometric sensor （LAPS） is addressed in detail based on our recent work and the research trends of olfactory biosensors in future are discussed.

关 键 词：嗅觉传导 仿生学 生物传感器 生物学 

分 类 号：Q811[生物学—生物工程]