甘露糖结合蛋白基因多态性与维吾尔族IgA肾病免疫病理类型的关系  

Association of mannose-binding protein gene polymorphism with different patterns of glomerular immune deposits in IgA nephropathy patients of Uygur nationality in Xinjiang

作　　者：陆晨[1] 朱开春[1] 岳华[1] 姜鸿[1] 徐世茹[1] 阿丽娅[1] 热孜万[1] 代建霞[1] 纪晓梅[1] 宋雪[1] 阿迪拉[1] 刘熔[1] 

机构地区：[1]新疆维吾尔自治区人民医院肾病科,乌鲁木齐830001

出　　处：《中华肾脏病杂志》2007年第7期434-437,共4页Chinese Journal of Nephrology

基　　金：新疆维吾尔自治区自然科学基金（20052118）

摘　　要：目的探讨甘露糖结合蛋白（MBP）基因多态性与维吾尔族IgA肾病（IgAN）患者免疫病理类型之间的关系。方法选择68例经肾活检证实的维吾尔族IgAN患者为对象，对照组为200例维吾尔族健康献血员。采用PCR-RFLP的方法对MBP基因第54位密码子基因多态性进行研究。结果（1）维吾尔族IgAN组与健康对照组MBP-54基因多态性之间差异无统计学意义。（2）维吾尔族IgAN复合沉积组GAC／GGC基因型频率显著高于单纯沉积组（44．7％比20．0％）；IgAN复合沉积组等位基因GAC的发生频率（0．303）显著高于单纯沉积组（0．133），2组之间的差异有统计学意义（χ^2=5．461，P〈0．05）。结论维吾尔族IgAN免疫病理多样性受基因背景影响，MBP基因54位点突变型等位基因GAC与维吾尔族IgA肾病免疫复合沉积有关。Objective To investigate the relationship of mannose-binding protein （MBP） gene polymorphism to various patterns of glomerular immune deposits in IgA nephropathy patients of Uygur nationality in Xinjiang. Methods Sixty-eight patients with biopsy-proven IgA nephropathy were identified from renal disease database. Two hundred healthy donors served as normal controls. MBP codon 54 gene polymorphism was detected by PCR-RFLP. MBP genotype and allele frequency were compared between different patterns of glomerular immune deposits in IgA nephropathy patients and normal controls. Results Distribution of MBP codon 54 gene polymorphism showed no signficant difference between Uygur IgA nephropathy patients and Uygur normal controls. Distribution of MBP gene polymorphism in Uygur IgAN patients with different patterns of immune deposits showed significant difference. The genotype frequency of GAC heterozygote was significantly higher in group with glomerular IgA, IgG, IgM, C3 and Clq deposits in the mesangium as compared to that in group with isolated IgA and C3 deposits （44.7% vs 20.0% ）, and as well as the GAC allele frepuency （0.303 vs 0.133）. Conclusions Immunopathological polymorphism of Uygur IgAN is influenced by genetic context. The GAC heterozygote of MBP gene codon 54 may contribute to different patterns of glomernlar immune deposits in Uygur IgAN patients.

关 键 词：肾小球肾炎 IgA 甘露糖结合凝集素类 维吾尔族 免疫沉积 

分 类 号：R686[医药卫生—骨科学]