氯诺昔康复合二异丙酚在无痛人工流产术中的应用  

Lornoxicam combined with propofol: applicate for painless artificial abortion

作　　者：苏中宏[1] 金毅[1] 徐建国[1] 贾真[1] 马欣[1] 

机构地区：[1]南京军区南京总医院南京大学医学院临床学院麻醉科,江苏南京210002

出　　处：《医学研究生学报》2007年第3期275-277,共3页Journal of Medical Postgraduates

基　　金：江苏省医学重点人才基金资助项目(批准号:RC2002058)

摘　　要：目的:研究氯诺昔康(商品名:可塞风)复合二异丙酚的麻醉效果及其对人工流产手术后疼痛的影响。方法:90例自愿行无痛人工流产手术患者随机均分为三组:D组单用二异丙酚麻醉;DF组使用芬太尼1μg/kg和二异丙酚麻醉;DL组使用氯诺昔康16mg和二异丙酚麻醉。以VAS评分评价患者清醒后即刻、5、10、20min及离院时的疼痛强度,同时观察术中体动反应强度、二异丙酚用量、唤醒时间及定向力恢复时间。结果:①术后疼痛VAS评分:DF组和DL组之间差异无显著性意义(P>0.05),但两组均明显低于D组(P<0.05),DL组清醒后20min及离院时明显低于DF组(P<0.05);清醒后各时间点VAS评分的差异有显著性意义(P<0.05)。②麻醉效果及对呼吸、循环的影响:和其他两组比较,DF组术中体动反应轻、二异丙酚用量少、唤醒时间和定向力恢复时间短(P<0.05);和麻醉前相比,DF组麻醉后3min的血压、心率、脉血氧明显降低(P<0.05);DF组心动过缓、呼吸抑制的发生率明显高于D、DL组(P<0.05)。结论:氯诺昔康复合二异丙酚麻醉,可有效地控制人工流产手术后疼痛,但术中镇痛作用欠佳。Objective：To investigate the analgesic efficacy of lomoxicam combined with propofol on pain followed by artificial abortion. Methods：Ninety patients were divided into three groups randomly to receive different anesthetics： propofol alone （group D） ; propofol and 1 μg/kg of fentanyl （group DF） ; lornoxicam 16mg and propofol （group DL）. VAS （visual analogue score） as the index of pain intensity,was recorded at five time-points： 0,5,10 and 20 minutes after patients recovering anesthesia and the patients left hospital. The degree of body motion during operation, the summed propofol, awake time and orientation recovery time were observed. Results：VAS was not different between group DF and group DL, but VAS in both groups were lower than in group D. VAS at 20 minutes and when patients left hospital were lower in group DL than in group DF. Compared with in group D and group DL, the degree of body motion was lighter, the summed propofol smaller, awake time and orientation recovery time shorter in group DF.Compared with pre-anesthesia, SBP, DBP, HR, SpO2after anesthesia were lower in group DF. The ratio of bradyeardia and respiration depression were more serious in group DF than that of other two groups. Conclusion： Lornoxieam combined with propofol could control the pain followed by artificial abortion, but the analgesic efficacy during operation is not sufficient.

关 键 词：氯诺昔康 人工流产 手术后疼痛 

分 类 号：R719.3[医药卫生—妇产科学]