1,25-二羟维生素D_3及其类似物对免疫系统的调节作用  

1,25-Dihydroxyvitamin D_3 and its analogs exert immunoregulatory activitives

作　　者：李培[1] 祁晓萍[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所,江苏南京210002

出　　处：《医学研究生学报》2007年第3期298-301,共4页Journal of Medical Postgraduates

基　　金：国家重点基础研究发展规化基金资助项目(批准号:2003CB515502)

摘　　要：1,25-二羟维生素D3是维生素D的活性形式,是一种第二类固醇类激素,和维生素D受体(VDR)结合发挥作用。VDR是核受体超家族中的一员,这一核受体超家族还包括类固醇激素受体,甲状腺激素受体和维甲酸受体。1,25-二羟维生素D3调节钙磷代谢,控制细胞的增殖和分化,产生免疫调节作用。对1,25-二羟维生素D3及其类似物功能研究的进展和免疫调节机制的新认识,提示它们在治疗自身免疫性疾病和诱导同种异体移植耐受上可有广泛的应用。1,25-二羟维生素D3及其类似物除了直接作用于T细胞外,还通过各种机制调节抗原呈递细胞的表型和功能,尤其是树突细胞。体内和体外实验都已证明1,25-二羟维生素D3及其类似物诱导树突细胞获得致耐受性,这一特性可被用于人类自身免疫性疾病及同种异体移植排斥的治疗。作者就1,25-二羟维生素D3及其类似物功能研究的新进展和免疫调节机制的新认识作一综述。The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [ 1,25 （ OH）ED3 ] ,is a secosteroid hormone that binds to the vitamin D receptor （VDR） , a member of the superfamily of nuclear receptors for steroid hormones ,thyroid hormone ,and retinoic acid. 1,25-Dihydroxyvitamin D3 and its analogue regulate calcium and bone metabolism, control cell proliferation and differentiation, and exert immunoregulatory activities. Recent advances in understanding their functions and novel insights into the immunomodulatory mechanisms they control suggest a wider applicability in the treatment of autoimmune diseases and induction of allograft tolerance. In addition to direct effects on T cell activation, 1,25-Dihydroxyvitamin D3 and its analogue modulate with different mechanisms the phenotype and function of antigen-presenting cells （APC） ,and, in particular,of dendritic cells （DC）. In vitro and in vivo experiments have shown that 1,25-Dihydroxyvitamin D3 and its analogue induce DC to acquire tolerogenic properties that favor the induction of regulatory rather than effector T cells. These intriguing actions of 1,25-Dihydroxyvitamin D3 and its nanlogue have been demonstrated in several experimental models and could be exploited, in principle, to treat a variety of human autoimmune diseases,or inhibit allograft rejection.

关 键 词：1 25-二羟维生素D3 自身免疫性疾病 移植排斥 

分 类 号：R593.2[医药卫生—内科学]