重型肝炎恢复期肝穿组织学随访研究  

Liver biopsy follow-up of severe hepatitis without clincal symptom

作　　者：王全楚[1] 申德林[1] 张燕[1] 朱晓红[1] 

机构地区：[1]解放军第153中心医院传染科,河南郑州450042

出　　处：《河南医学研究》2007年第2期111-113,共3页Henan Medical Research

基　　金：河南省科学技术厅科技攻关项目资助课题(96031)

摘　　要：目的:阐明重型肝炎治愈后肝脏组织学的变化规律,更好的指导临床治疗。方法:采用Menghini一秒钟肝穿活检法对临床治愈的19例重型肝炎病人,在临床治愈后3个月、6月、12月分别进行肝穿病理组织学检查。结果:19例病人中炎症分级G2、G3分别为9例、10例,纤维化分期S2、S3、S4分别为8例、7例、4例,肝组织免疫组织化学检查HBsAg阳性17例,HBcAg阳性15例。结论:已经临床治愈出院的重型肝炎病人肝穿组织学发现仍然存在明显的炎症活动和纤维化,提示重型肝炎临床治愈后的恢复和重建是一个漫长而复杂的过程。Objective： Severe hepatitis treated with conservative therapy has a poor prognosis, although individual survival varies greatly. The aim of this study was to assess the role of Liver biopsy follow-up in the management of patients with no symptom. Methods ： Nineteen patients with the clinical presentation of ALF were referred to our institution during a 3 month period. Liver biopsy was performed using the Menghini methods. Clinical data, procedural complications, and histological findings were evaluated. Results ： Liver biopsy was technically successful in all patients without procedure-related complications. Histological activity and necrosis G2 and G3in 19 patients were 9 cases and 10 cases represently, S2,S3,S4 were 8 cases,7 cases,4 cases represently . There was a strict statistical correlation between the poor prognosis and the necrosis found at routine histological examination. Conclusion： In patients without clinical symptom of Severe hepatitis, Liver biopsy can be a quick and effective tool in clinical decision-making, especially in deciding patient having a long time therapy.

关 键 词：重型肝炎 恢复期 肝穿组织学 随访 

分 类 号：R51[医药卫生—内科学]