人心脏缺血预处理对非同一缺血部位心肌的保护作用  

Protective Effects of Regional Ischemic Preconditioning on Human Nonidentical Ischemic Myocardium

作　　者：刘小青[1] 陈玉玺[1] 李珊[1] 魏经汉[2] 魏太星[2] 

机构地区：[1]开封解放军第155医院心内科,开封475003 [2]河南医科大学第一附属医院心内科

出　　处：《基础医学与临床》1997年第1期25-28,共4页Basic and Clinical Medicine

摘　　要：观察在双支经皮冠状动脉腔内成形术（PTCA）中缺血预处理对非同一缺血部位心肌的作用。14例患者均为两支冠状动脉（冠脉）病变。分别观察两支冠脉成形时心绞痛程度、狭窄冠脉相关导联心电图最大ST段抬高幅度和发生时间双冠状窦静脉血浆和血清中血栓素B2（TXB2）和6-酮─前列腺素F1α（6－keto－PGF1α）浓度。观察到两支冠脉狭窄程度及PTCA参数无明显差别，但第二支冠脉PTCA时心绞痛积分及发生时间和心电图最大ST段抬高幅度及发生时间均显著低于或迟于第一支冠脉PTCA时（P＜0.05）。第二文冠脉PTCA前后血浆6－keto－PGF1α水平均高于第一支（P＜0．05）。提示缺血预处理可以保护非同一缺血部位的心肌，其机制可能同前列环素的改变有关。In this study,effects of regional ischernic preconditioning on remote myocardium was observed. Fourteen patients of coronary heart diseases with two branch coronary stenosis were undergone percutancous transluminal coronary angioplasty. The score of anginal intensity, the height of ST segmcnt. shift and their initial times were observed during first and second coronary angioplasty. In same times, the level of thromboxane B2 (TXB2 )and 6-keto-prostaglandin F1a (6-keto-PGF1a)in coronary venous blood were mcasured. Between two coronary branches,the stenosis degree were not different. The score of anginal intensity and the height of ST sepment shift in second coronary angiopfasty were lower than that in first coronary. Their initial times were delayed more than that in first coronary. Before and after coronary angioplasty, the level of 6-keto-PGF1a in first coronary was higher than that in second coronary. We conclude that regional ischemic preconditioning can protect remote myocardium and it is relation to the levecl of 6-keto-PGF1a.

关 键 词：预处理 心肌缺血 保护作用 

分 类 号：R541.405[医药卫生—心血管疾病]