诺氟沙星注射液在兔体内的药代动力学研究  

PHARMACOKINETIC STUDY ON NORFLOXACIN INJECTION IN RABBITS

作　　者：曾昭贤[1] 包定元[1] 刘小康[1] 肖逸[1] 

机构地区：[1]华西医科大学基础医学院,成都610041

出　　处：《华西药学杂志》1997年第1期4-5,共2页West China Journal of Pharmaceutical Sciences

摘　　要：家兔10只，均分为两组，分别静脉及肌肉注射谱氟沙星注射液10mg／kg，用HPLC测得经时血药浓度。结果显示其两种给药途径的药时曲线均符合二定模型．其主要药动学参数静脉注射组为：C0（13．90±3．43）μg／ml，1/2：α（0.11±0．04）h．t1/2β（2．45±0．64）h，Vd（1．29±0．32）L/kg，AUC（10．39±2．60）mg·h／L，CL（2．01±3．47）L／kg·h；肌肉注射组为；Cmax（2．69±0．63）μg／ml，Tmasx（016±0．12）h，t1/2：Ka（0．02±0.03）h，t1/2α（0．53±0．56）h，t1/2β（2．83±0．47）h，Vd（7．60±1．63）L/kg，AUC（9．46±1．47）mg·h／L，CL（2．14±0．34）L／kg·h．F91％．The pharmacokinetics of norfloxacin inkction was reported. Ten rabbits were divided randomly into two groups (5 per goup ), and then received a singl dose 10mg/kg intravenous and intramuscular of norfloxacin injection, respectively. Serum concentrations of nornloxacin were determined by HPLC. The drug concentration-time profile conformed to the two-compartment open model in all the rabbits. The pharmacokinetic parameters of norfloxacin in the iv group were: C0 (13' 90± 3. 4)μg/ml, t3/2α (0. 11 ± 0.04)h, t1/2β(2. 45 ±0. 64, h, Vd (1. 29 ± 0. 32 )L/kg, AUC(10. 39± 2. 60)mg' h/L, CL (2. 01 ±0. 47 )L/kg ' h； and in the im group were: Cmax (2. 69 ± 0. 63)μg/ml, Tmax (0.16 ± 0. 12)h, t1/2Ka (0. 02 ± 0. 03 )h, t1/2α(0. 53 ± 0. 56)h, t1/2β(2. 83 ±0. 47)h, Vd (7. 60±1. 63)L/kg, AUC(9. 46± 1. 47)mg' h/L, CL (2.14 t 0- 34)L,kg' h, F91 %. The results showed that norfloxacin im was absorbed rapidly and had ahigh absolute bioavailability.

关 键 词：诺氟沙星 注射液 药代动力学 

分 类 号：R978.19[医药卫生—药品]