低剂量辐射对大鼠脏器及骨髓微核细胞的影响  

EFFECT OF LOW DOSE IRRADIATION ON VISCERA AND BONE MARROW MICRONUCLEI IN RATS

作　　者：金宏[1] 高兰兴[1] 许志勤[1] 王宗印[1] 徐登云[1] 顾景范[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所

出　　处：《解放军预防医学杂志》1997年第1期12-15,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：全军"八五"课题资助

摘　　要：本实验采用２３．５ｍＧｙ照射剂量、每周一次，三个月后，胸腺百克体重指数比对照组明显增加，脾脏ＲＮＡ水平和骨髓细胞微核发生率有增加的趋势，但均无统计学显著性；组织形态学观察，胸腺髓质扩大，其他脏器未见变化。结果提示，低剂量辐射对机体免疫器官有剌激作用，对细胞遗传性有产生影响的趋势，因此，对接触放射性物质的人员有必要从营养的角度减少辐射对机体正常代谢的影响。30 male Wistar rats were randomly alloted to two groups. The experimental rats were once a week subjected to whole body 137 Cs-irradiation with dose of 23.5mGy for 3 months, and the total irradiated dose was 280mGy. The control group was raised normally. The effect of low dose irradiaton on viscera and bone marrow micronuclei was observed. The results showed that the weight of thymus was remarkably higher than that of the control.As compared with control group the level of RNA in spleen and the quantity of bone marrow micronuclei increased, but all of these changes did not have any statistical significance.The observation on histology showed the medulla in thymus was a little increased, but no change in other viscera. The results suggested that the immune organ was stimulated and genetic function was influenced following low dose irradiation. Thus the person should increase the mutritional supplement,to protect against the effect of irradiation on metabolism.

关 键 词：低剂量辐射 脏器 骨髓 微核细胞 

分 类 号：X591[环境科学与工程—环境工程]