四丙酰关附醇胺对大鼠离体心脏再灌性心律失常及心肌离子含量的影响  

Effects of tetrapropinyl guan fu alcohol amine on reperfusion induced arrhythmias and electrolyte contents in isolated rat hearts 1

作　　者：朱东亚[1,2,3] 王如斌[1,2,3] 彭元瑜 

机构地区：[1]中国药科大学新药研究中心 [2]山东医科大学药学系药物化学教研室 [3]海口市制药厂

出　　处：《中国药理学与毒理学杂志》1997年第1期31-34,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：江苏省科委应用基础研究基金

摘　　要：在大鼠离体Ｌａｎｇｅｎｄｏｒｆ灌流心脏观察四丙酰关附醇胺（ＴＰＧＦＡ）对再灌性心律失常及心肌Ｎａ＋，Ｋ＋，Ｃａ２＋水平的影响．ＴＰＧＦＡ６－１２ｍｇＬ－１显著降低３０ｍｉｎ缺血＋３０ｍｉｎ复灌和吡那地尔（１．２５μｍｏｌＬ－１）＋１２ｍｉｎ缺氧＋４０ｍｉｎ再给氧两种模型的室性心动过速和心室纤颤发生率；ＴＰＧＦＡ３－１２ｍｇＬ－１可显著减慢心率，延长心电图的ＱＴｃ，减少Ｋ＋从心肌细胞内丢失；１２ｍｇＬ－１时还减少细胞内Ｃａ２＋堆积．结果表明ＴＰＧＦＡ可保护大鼠离体心脏的再灌性心律失常，其作用机理可能与抑制外向Ｋ＋电流有关．The effects of tetrapropinyl guan fu alcohol amine(TPGFA) on the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) induced by reperfusion and the contents of Na +, K + and Ca 2+ were studied in isolated rat hearts. Ischemia (30 min) followed by 30 min reperfusion, VT and VF occurred in 8/8 and 7/8 hearts respectively; in contrast, those occurred in 3/8 and 1/8 hearts exposed to 6 mg·L 1 TPGFA, and 1/8 and 0 hearts exposed to 12 mg·L 1 TPGFA respectively. All hearts (8/8) subjected to pinacidil (1.25 μmol·L 1 ) plus 12 min hypoxia and 40 min reoxygenation developed VT and VF. However the incidence of VT and VF in hearts reperfused was 3/8 and 2/8 respectively in the presence of 6 mg·L 1 TPGFA, and that was 1/8 and 0 respectively in the presence of 12 mg·L 1 TPGFA. TPGFA at concentrations of 3-12 mg·L 1 significantly protected hearts against K + loss and prolonged QT c of ECG induced by ischemia reperfusion. The results suggest that TPGFA inhibits ischemia reperfusion induced myocardial K + loss and protects the heart against life threaten reperfusion arrhythmias.

关 键 词：四丙酰关附醇胺 再灌注 心律失常 钠 钾 钙 

分 类 号：R972.2[医药卫生—药品] R541.705[医药卫生—药学]