HLA-DRB和ACE基因与肺结核的相关性分析  

Association of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis

作　　者：时广利[1] 胡秀玲[1] 荣长利[1] 张宝秋[1] 宋长兴[1] 

机构地区：[1]北京市结核病胸部肿瘤研究所,北京101149

出　　处：《中国防痨杂志》2007年第4期327-329,共3页Chinese Journal of Antituberculosis

摘　　要：目的探讨人类白细胞抗原(HLA)-DRB基因和血管紧张素转换酶(ACE)基因多态性与肺结核的相关性。方法采用聚合酶链反应-序列特异性引物法(PCR-SSP)对肺结核组和健康对照组进行HLA-DRB和ACE基因分型。结果肺结核组HLA-DRB1*15等位基因的频率显著高于对照组(P<0.05);复治和耐药肺结核组ACE基因的I/D基因型频率显著高于初治和无耐药组(P<0.05)。结论HLA-DRB1*15等位基因及ACE基因的I/D基因型与肺结核密切相关。Objective To analyze the relation of polymorphisms of HLA-DRB gene and ACE gene with pulmonary tuberculosis. Methods PCR/SSP was used to identify the HLA-DRB and ACE genotype in pulmonary tuberculosis group and control group. Results The frequency of HLA-DRB1 ＊ 15 allele in pulmonary tuberculosis group was significantly higher than that in control group（ P 〈 0.05）. The frequency of ACE I/D genotype in retreatment and drug-resistant pulmonary tuberculosis group was significantly higher than that in initial and drugsensitive group（ P 〈 0.05）. Conclusion The HLA-DRB1 ＊ 15 allele and the I/D genotype of ACE gene were evidently associated with pulmonary tuberculosis.

关 键 词：HLA-DRB基因 ACE基因 结核 肺 

分 类 号：R521[医药卫生—内科学]