2种新型基因工程长效人胰岛素类似物  

Two novel long acting human insulin analogs produced by genetic engineering

作　　者：高剑坤[1] 蔡绍皙[1] 范开[2] 龙波 

机构地区：[1]重庆大学生物工程学院,重庆400044 [2]重庆工学院,重庆400050 [3]绵阳市四零四医院,四川绵阳621000

出　　处：《中国新药与临床杂志》2007年第7期548-552,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：甘精胰岛素和地特胰岛素是2种新型的人胰岛素类似物。虽然他们都通过基因工程的方法生产,药效能持续24h,无明显的波峰和波谷,是真正意义上的基础胰岛素,但是这2种长效胰岛素的分子结构、长效机制、生产工艺各不相同,在临床使用上也有各自的利弊。Insulin glargine and insulin detemir are both of human insulin analogs, produced through genetic research engineering. They are both basal insulins; because of they can remaining active for a full 24 hours with essentially no peaks or valleys, but having different molecular structure, long acting mechanisms, artworks and different clinical effects.

关 键 词：甘精胰岛素 地特胰岛素 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R977.15[医药卫生—内科学]