抗逆转录病毒药物治疗8例获得性免疫缺陷综合征1年的疗效  

Clinical efficacy in 8 acquired immunodeficiency syndrome patients treated with antiretroviral drugs

作　　者：尹春煜[1] 卢洪洲[2,3] 李晓鸥[1] 娄国强[1] 胡越凯[2] 潘孝彰[2] 翁心华[2] 

机构地区：[1]杭州市第六人民医院传染科 [2]复旦大学附属华山医院传染科 [3]上海市公共卫生中心传染科,上海,201508

出　　处：《中国新药与临床杂志》2007年第7期557-560,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:观察国产去羟肌苷散、司他夫定和奈韦拉平联合治疗获得性免疫缺陷综合征(艾滋病)病人1a的初步疗效、不良反应以及耐药性突变位点。方法:艾滋病病人8例,给予去羟肌苷、司他夫定和奈韦拉平3药联合治疗,在治疗前和治疗1,3,6,9,12mo时定期监测病人的血浆病毒载量及CD4+T淋巴细胞计数,评价药物不良反应,并对基线及治疗1a的标本进行基因型耐药性检测。结果:治疗后病人血浆中病毒载量均明显降低(P<0.01),CD4+T淋巴细胞数量增加(P<0.01)。早期的药物不良反应较少,当治疗1a后至少有2例病人对治疗药物产生了耐药性。结论:国产3药联合治疗在早期就能有效抑制艾滋病病毒的复制,机体免疫功能也有改善,耐受性良好,后期则可以发生耐药性变异。AIM： To observe the efficacy, adverse reactions and drug-resistant mutations of antiretroviral therapy with domestic drugs in acquired immunodeficiency syndrome （AIDS） patients. METHODS： Eight AIDS patients were treated with didanosine, stavudine and nevirapine combined therapy. All patients were followed up for 12 months with measurements of plasma HIV-1 RNA level and CD4^＋T cell count of the patients at baseline and the ends of the 1 st, 3 rd, 6 th, 9 th and 12 th month; together with record of adverse reactions. Genotype resistance assays were performed for 12 th month specimens. RESULTS： The level of plasma HIV-1 RNA decreased and CD4^＋ cell count increased significantly in each of 8 patients, while the adverse reactions of the three drugs were mild in the early stage. Drug resistance mutations emerged in two patients after one year therapy. CONCLUSION： The regimen with combined three domestic drugs could suppress HIV reproduction and improve immunological function with well toleration in the earlier period, but resistance mutations lead to rebound of viral load.

关 键 词：获得性免疫缺陷综合征 病毒载量 抗逆转录病毒治疗 高效 耐药性 

分 类 号：R512.91[医药卫生—内科学] R978.7[医药卫生—临床医学]