大黄■丸对肝硬化患者血清胰岛素样生长因子的影响  

Effect of Dahuangzhechong Pill on Insulin-like Growth Factor of Hepatocirrhosis

作　　者：俞翁非[1] 胡少龙[1] 施昕[1] 傅跃娟[1] 黄伟[1] 

机构地区：[1]浙江省金华市中心医院,金华321000

出　　处：《浙江中西医结合杂志》2007年第8期469-470,共2页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨大黄■虫丸对肝硬化患者血清IGF-Ⅰ、IGF-Ⅱ、IGFBP-3的影响。方法:将100例肝炎肝硬化患者随机分为两组,对照组常规护肝对症治疗,治疗组在此基础上加用大黄■虫丸,1次3g,每天2次,疗程2个月。观察治疗前后血清ALT、AST、TBiL及IGF-Ⅰ、IGF-Ⅱ、IGFBP-3水平的变化。结果:治疗结束后治疗组血清ALT、AST、TBiL水平明显下降(P<0.05),IGF-Ⅰ、IGF-Ⅱ、IGFBP-3水平明显提高。结论:大黄■虫丸是治疗肝硬化的有效药物,可明显改善肝功能,同时改善IGF-Ⅰ、IGF-Ⅱ、IGFBP-3水平。IGF-Ⅰ、IGF-Ⅱ、IGFBP-3是有价值的肝功能测评指标。Objective：To obverse the effect of Dahuangzhechong pill on levels of IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 in the blood serum of hepatocirrhosis. Methods： 100 cases of hepatocirrhosis were randomly divided into the contrast group and the treatment group. The contrast group was treated by normal medicine to protect liver and the treatment group by Dahuangzhechong pill twice every day with 3g every time additionally. The period of therapy was two month. The levels of ALT, AST, TBIL, IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 in the blood serum were observed before and after therapy. Results：After therapy the levels of ALT, AST and TBIL in the treatment group were obviously decreased （ P 〈 0.05 ） and the levels of IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 improved. Conclusion：Dahuangzhechong pill has good effect on treating hepatocirrhosis, and can improve the function of liver and the levels of IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 significantly. IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 are effective indexes to evaluate the function of liver.

关 键 词：肝硬化 血 清 胰岛素样生长因子 结合蛋白 大黄[庶虫]虫丸 

分 类 号：R259[医药卫生—中西医结合]