新型氨基化磁性纳米粒子的合成  

Synthesis of a newly aminated magnetic nanoparticles

作　　者：肖旭贤[1] 何琼琼[2] 覃罡[3] 黄韵如[3] 蹇文灵[3] 黄婉媛[3] 

机构地区：[1]中南大学化学化工学院,湖南长沙410083 [2]中南大学基础医学院,湖南长沙410078 [3]中南大学湘雅医学院,湖南长沙410078

出　　处：《应用化工》2007年第7期641-643,655,共4页Applied Chemical Industry

基　　金：国家自然科学基金项目(30671846)

摘　　要：通过嫁接方法在包有二氧化硅的纳米CoFe2O4磁粒表面进行氨基化修饰,制备出一种可用于生物医学领域的新型氨基化纳米磁粒,采用TGA-DTA,IR,VSM和Zeta-potential等测定方法,对氨基化和未氨基化的CoFe2O4纳米粒子进行了表征。元素分析结果显示,有0.98 mmol/g的有机分子固定在纳米粒子表面;红外和热分析数据显示,带氨基的有机分子嫁接到磁粒表面的二氧化硅壳层上;Zeta电位数据也显示,带氨基的有机分子嫁接到纳米磁粒表面;样品的磁性参数显示,氨基化纳米磁粒仍具有好的磁学性能。Synthesis of a kind of newly aminated CoFe2O4 nanoparticles by grafting process for biomedical applications,which were coated primarily with silicon dioxide（ SiO2 ）. The aminated SiO2/CoFe2O4 （ASCN） and SiO2-coated CoFe2O4（SCN） nanoparticles were investigated by elemental analysis,TGA-DTA, IR,Zeta-potential measurement and VSM. Based on IR and TGA results,it was suggested that the surface of the SiO2-coated CoFe2O4 nanoparticles were grafted with amino compounds. The elemental analysis also showed that 0.98 mmol/g of organic moieties immobilized on the surface of ASCN nanoparticles. Zeta-potential data of ASCN nanoparticles also revealed that amino compounds was bonded onto the surface of SiO2-coated CoFe2O4 nanoparticles by ether linkage. The magnetic parameters showed that ASCN nanoparticles still had good magnetic behavior.

关 键 词：纳米磁性 铁酸钴 氨基化 嫁接 表面修饰 ZETA电位 

分 类 号：TQ138.1[化学工程—无机化工]