局部注射抗生素防治烧伤外伤感染(附65例分析)  

Treatment of infection on burn and wound by local antibiotics injection in the infections area (Analysis of treatment 65 patients)

作　　者：韩风华[1] 陈璧[1] 辛晓燕[2] 

机构地区：[1]第四军医大学西京医院烧伤科,西安710033 [2]第四军医大学西京医院妇产科,西安710033

出　　处：《第四军医大学学报》1997年第1期63-65,共3页Journal of the Fourth Military Medical University

摘　　要：通过动物实验模型观察Ⅲ度烫伤焦痂下局部植入绿脓杆菌，感染区不同部位注入抗生素的药物代谢和药效动力学变化，以便好地预防治疗外科局部感染患者。纯种家兔２１只随机分成三组：Ⅰ组（焦痂下局部用药），Ⅱ组（静脉给药）和Ⅲ组９不给药）。２１吸兔均用９０℃恒温热水烫及背部实验区４０ｓ制作总面积１５％Ⅲ度烫伤模型，烫伤后第７日焦痂注入绿脓杆菌菌液，第９日液药，检药。Objective:The local pharmackinetic and pharmacdynamics were studied by the animal experimentin order to treat patients with local infection more effectively. Methods: The 21 rabbits (New Zealand) were randomly divided into three groups: Ⅰ [cefoperazone (CPZ) administered on the subeschar], Ⅱ (CPZ administered intravenous) and Ⅲ (No to administer CPZ). The model pattern of scald and infection was made: all of rabbit's experimental areas was scalded ( Ⅲ°TBSA 15%) by exposing to the hot water at 90℃ for about 40 seconds. After 7 days pyocyaneus bacilli (108/ml) were injected on subeschar and after 9 days the CPZ was injected into subeschar of group Ⅰ and into intravenous of group Ⅱ (25 mg/kg). Blood subeschar tissue fluid (STF) samoles was collected at specific times and concentration of CPZ were measured. The experimental data were analyzed by computer. The 65 patients with local infection were treated by the method of local injection antibiotics. Results: (1) Cmax, is higher (2681. 39 mg/L) and T1/2e is longer (9. 03 h) in group Ⅰ than in group Ⅱ . (2) The survival rat in group Ⅰis more. (3) The 65 patients with local infection were cured by the method of local injection antibiotics. Conclusions: The method of antibiotics injected in infectious area is better to control local infection. The antibiotics was injected with the interval of 48 hours for the treatment and 72 hours for prevention on local infections patients. The dose of the antibiotics by each local injection is equal to or less than that by intraveuous ones. This method is easy to conduct, with a high cure rate and littleside effect.

关 键 词：局部感染 抗生素 烧伤 防治 

分 类 号：R644.06[医药卫生—外科学]