前列地尔治疗老年2型糖尿病伴微量白蛋白尿及运动诱发白蛋白尿的临床观察  

Clinical observation of Lipo prostaglandin E_1 in treating exercise-induced microalbuminuria or microalbuminuria in aged patients with type 2 diabetes

作　　者：祝开思[1] 严亦夏[2] 王平[1] 曲建昌[1] 袁风仪[1] 刘长伟[1] 

机构地区：[1]解放军305医院内分泌科,北京100017 [2]解放军305医院抗衰老中心,北京100017

出　　处：《中国临床保健杂志》2007年第4期372-374,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的观察前列地尔(prostaglandin E1)注射液治疗老年2型糖尿病微量白蛋白尿及运动诱发微量蛋白尿的临床疗效。方法将老年2型糖尿病肾病微量白蛋白尿及运动诱发微量蛋白尿患者64例,年龄60～78岁,随机分为治疗组34例和对照组30例。两组患者根据尿蛋白不同再分别分为运动诱发蛋白尿组、微量蛋白尿组2个亚组。治疗组给予静脉注射前列地尔10μg/d,疗程20 d。对照组不给以上治疗。观察治疗前后尿微量蛋白排泄率变化。结果前列地尔治疗后,尿微量白蛋白及运动诱发微量蛋白明显下降,与治疗前及对照组差异有统计学意义(P<0.01)。治疗后12个月,复查结果显示,治疗组患者微量尿白蛋白及运动诱发蛋白水平无明显变化。结论短期使用前列地尔对糖尿病肾病可明显降低尿微量白蛋白,尤其是运动后蛋白尿疗效显著。Objective To evaluate the effect prostaglandin El （ Lipo PGE1 ） in treating exercise - induced microalbuminuria or in aged patients with type 2 diabetes. Methods 64 aged patients with diabetic nephropathy were conducted into two groups. According to the excretion of urinary albumin, We evaluated the change of proteinuria for 2 subgroups（ exercise - induced microalbuminuria and microalbuminuria）. 34 patients were treated for twenty days with intravenous infusion of 10 μg Lipe PGE1 per day . 30 patients in control group. The urinary albumin excretion were observed. Results After the treatment, urinary albumin excretion and exercise - induced micro - albuminuria decreased significantly （P 〈 0. 01 ） compared with control group and the basal value. Conclusion Short - term application of Lipo PGE1 is effetive in decreasing urinary albumin excretion and exercise - induced micro - albuminuria.

关 键 词：糖尿病肾病 白蛋白尿 前列地尔 

分 类 号：R587.2[医药卫生—内分泌]