抗反流治疗对阻塞性睡眠呼吸暂停低通气综合征疗效观察  

The effect of anti-acid reflex therapy in treating patients with obstructive sleep apnea hyponea syndrome

作　　者：李羚[1] 胡贤珍[1] 冯益进[1] 

机构地区：[1]安徽合肥市第一人民医院耳鼻咽喉科,230061

出　　处：《中国临床保健杂志》2007年第4期385-386,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨抗反流治疗是否能有效缓解合并反流症状的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)。方法将40例经多导睡眠(PSG)监测诊断为OSAHS,并主诉有夜间反酸、烧心、胸骨后疼痛等反流症状的患者予以:莫沙必利和奥西康抗反流治疗1周后重复PSG监测。结果抗反流治疗后,呼吸暂停/低通气指数(AHI)从(65.8±17.9)/h下降到(48.3±10.4)/h(P<0.01),其中呼吸暂停指数(AI)由(38.5±13.6)/h降到(9.2±7.8)/h,低通气指数(HI)由(27.3±17.0)/h上升到(39.1±13.8)/h,最低血氧没有改善。结论抗反流治疗在加快对反流物的清除的同时可部分降低AHI,但仍然不能完全缓解OSAHS,且对血氧无明显影响,仅可作为辅助治疗。Objective To observate the therapeutic effect of anti -acid reflex in treating OSAHS patients with acid reflex. Methods 49 patients with OSAHS diagnosed by polysomnography （PSG） and acid reflex were giv- en mosapride and omeprazole to treat the gastric acid reflex, then the PSG was monitored again after one week treatment. Result After one week treatment, Apnea/hypo - ventilation index （AHI） increased significantly from 65.8 ± 17.9/h to 48.3 ± 10.4/h, apnea index decreased markedly from 38.5 ± 13.6/h to 9.2 ± 7.8/h, hypo - ventilation index increased from 27.3 ± 17.0/h to 39.1 ± 13.8/h, however blood minimum blood oxygen concentration had no change. Conclusion Anti - acid reflex therapy can be used as a assisted means in the treatment of patients with OSAHS and gastric acid reflex.

关 键 词：睡眠呼吸暂停 阻塞性 胃食管反流 抗酸剂 

分 类 号：R766[医药卫生—耳鼻咽喉科]