当归对阻塞性黄疸患者淋巴细胞IL-2活性和IL-2R表达的影响  

Effect of Angelica Sinensis on Cellular Immunity in Patients with Obstructive Jaundice

作　　者：李延光[1] 邹声泉[2] 

机构地区：[1]解放军第161中心医院普通外科,武汉430010 [2]华中科技大学同济医学院附属同济医院普通外科,武汉430030

出　　处：《中国普外基础与临床杂志》2007年第4期456-458,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨围手术期当归对阻塞性黄疸患者细胞免疫功能的调节作用。方法用当归注射液围手术期对患者进行治疗(共14d),观察其外周血淋巴细胞IL-2的活性及IL-2R表达的变化。结果阻塞性黄疸患者血淋巴细胞IL-2活性及IL-2R表达阳性率与正常人相比均明显下降(P<0.01)。给予当归治疗后,发现术前其IL-2活性及IL-2R表达阳性率均明显升高(P<0.01),术后其IL-2活性及IL-2R表达阳性率与术前相比虽略有下降,但与用药前相比仍有明显升高(P<0.01)。结论围手术期应用当归具有改善阻塞性黄疸患者细胞免疫功能状态的临床实用价值。Objective To study the regulative effect of angelica sinensis on cellular immune function in perioperative patients with obstructive jaundice. Methods Fourteen patients with obstructive jaundice were injected with angelica before and after operation for 14 days. The activity of IL-2 and the expression of IL-2R in lymphocytes in peripheral blood were measured, respectively. Results The activity of IL-2 and the expression of IL-2R decreased significantly in patients with obstructive jaundice （P〈0.01）. The activity of IL-2 and the expression of IL-2R in peripheral blood lymphocyte increased significantly before and after operations （after treatment using angelica） （P〈 0.01）, though there was a little decrease after operation but they were still higher than that befor using angelica. Conclusion It maybc useful to use angelica to improve the cellular immune function in patients with obstructive jaundice.

关 键 词：阻塞性黄疸 细胞免疫 白细胞介素-2 白细胞介素-2受体 当归 

分 类 号：R26[医药卫生—中医外科学]