多波长直线回归法测定氯地滴眼液中的氯霉素和地塞米松磷酸钠  

Determination of chioramphenicol and dexamethasone sodium phosphate in eye drops by multiwavelength linear regression spectrophotometry

作　　者：黄喜茹[1] 刘增娟[2] 栗辉[1] 高洁[1] 

机构地区：[1]河北医科大学药学院分析化学教研室,河北石家庄050017 [2]河北石家庄市第三医院,河北石家庄050011

出　　处：《计算机与应用化学》2007年第7期953-955,共3页Computers and Applied Chemistry

摘　　要：研究建立测定氯地滴眼液中氯霉素和地塞米松磷酸钠含量的多波长直线回归法。在238.0 nm-290.0 nm波长区间,选择42个波长点作测定;采用计算机多波长直线回归程序作计算;不经分离,直接测定氯地滴眼液中氯霉素和地塞米松磷酸钠的含量。二者的平均回收率和相对标准偏差,分别为99.5%,1.1%和100.7%,1.3%。该方法简单、快速、准确、适用于氯地滴眼液的质量控制。To determine the contents of chloramphenicol and dexamethasone sodium phosphate in eye drops using calculator programmuhiwavelength linear regression spectrophotometry. The 42 wavelengths at 238.0 nm - 290.0 nm were selected as the measuring wavelengths ,it was applied that program of muhiwavelength linear regression spectrophotometry, the method was applied for the direct determination of chloramphenicol and dexamethasone sodium phosphate in eye drops without any preliminary separation. The average recoveries and relative standard deviations of chloramphenicol and dexamethasone sodium phosphate were 99.5% , 1. 1% and 100.7% , 1.3% ,respectively. The method was modern, simple, rapid, accurate, which can be used for quality control of eye drops.

关 键 词：氯地滴眼液 氯霉素 地塞米松磷酸钠 计算机程序-多波长直线回归法 

分 类 号：R927.2[医药卫生—药学]