哈尔滨地区应用重组人生长激素治疗儿童矮小的病因学调查  

Etiologic investigation of children with short stature applying rhGH in Harbin

作　　者：赵雪妮[1] 吴丹红[1] 王艳菊[1] 

机构地区：[1]黑龙江省医院儿科,哈尔滨150036

出　　处：《中华妇幼临床医学杂志（电子版）》2007年第4期197-198,共2页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：黑龙江省自然科学基金资助项目(D2004-36)

摘　　要：目的调查哈尔滨地区接受重组人生长激素(rhGH)治疗的矮小儿童219例,探讨其病因分布情况。方法采用统一的调查表,对219例矮小儿童,男性患儿147例(67.1%),女性72例(32.9%),通过查阅病案,获取病史、体格检查及相关实验室检查资料,分析病因学分布情况。结果本组219例应用rhGH的矮小儿童中,因生长激素缺乏(growth hormone deficiency,GHD)应用的为133例(60.8%),特发性矮小为60例(27.4%),Turner综合征为15例(6.9%),其余为宫内发育迟缓、性早熟、多种垂体激素缺乏症、软骨发育不全、甲状腺功能减低症患儿。结论哈尔滨地区应用rhGH的矮小儿童,均为疗效确定的适应证患者。其中,以GHD最为多见,特发性矮小者居第2位,Turner综合征为第3位,其他原因应用rhGH的矮小儿童构成比比较,差异无显著意义。Objective 219 children with short stature applying rhGH in harbin were investigated, etiologic distribution was explored. Methods 219 children with short stature applying rhGH were collected by unified investigation table,among them 147 were males （67. 1%）, 72 were female （32. 9%）, Distribution of disease eause is analyzed through all of the ehildren eolleeted detail medieal history and taken both physical and laboratory examination. Results Children with short stature applying rhGH, 133 eases （60.8%）were diagnosed as growth hormone defieieney（GHD）, 60 eases （27.4%）were diagnosed as idiopathic short stature, 15 eases （6. 9%）were diagnosed as Turner syndrome;The rest of the short statures were attribute for the other reasons. Conclusion Children with short stature applying rhGH in Harbin were indieation,GHD is a common disease among them, the second is idiopathic short stature, the third is Turner syndrome, the constituent ratio of other reasons of children with short stature applying rhGH was no signifieant differenee.

关 键 词：矮小 儿童 病因 生长激素 

分 类 号：R725.8[医药卫生—儿科]