辛伐他汀干预大鼠高肺血流所致肺动脉高压的机制  

Mechanism of Simvastatin on Pulmonary Hypertension Induced by High Pulmonary Blood Flow in Rats

作　　者：文德[1] 王敏[1] 宋志强[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院儿科,湖北宜昌443003

出　　处：《实用儿科临床杂志》2007年第13期1006-1008,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的了解辛伐他汀干预高肺血流所致肺动脉高压(PH)的作用机制。方法对大鼠行腹主动脉-下腔静脉分流术建立高肺血流所致PH动物模型,予辛伐他汀片2mg/(kg.d)干预11周后行肺动脉压力测定、检测肺血管平滑肌细胞凋亡率和肺血管平滑肌细胞增殖率并与无分流组和分流组比较。结果辛伐他汀能较好的降低肺动脉压力,辛伐他汀组大鼠肺动脉压力明显低于分流组大鼠;辛伐他汀能很好的诱导肺血管平滑肌细胞凋亡和抑制肺血管平滑肌细胞增殖;辛伐他汀组大鼠肺血管平滑肌细胞凋亡率明显高于分流组和无分流组(Pa<0.01);而辛伐他汀组大鼠的肺血管平滑肌细胞增殖率明显低于分流组和无分流组(Pa<0.01)。结论辛伐他汀通过诱导肺血管平滑肌细胞凋亡和抑制肺血管平滑肌细胞增殖对高肺血流导致的PH起较好的干预作用。Objective To comprehend the action mechanism of simvastatin in pulmonary hypertension （PH） when it induced by high pulmonary blood flow. Methods Abdominal aorta - inferior vena cava shunting was made in rats to establish animal model of PH induced by high pulmonary blood flow, simvastat/n with dose of 2 mg/（kg · d） was used to interfere for 11 weeks. And then, pulmonary arterial pressure,apoptosis rate and proliferation rate of pulmonary vascular smooth muscle cell were determined. Results were compared with other groups. Results Simvastatin could cut down the pulmonary arterial pressure well, pulmonary arterial pressures of simvastatin group rats were lower than those of spliting groups obviously（ P〈 0.01 ）. It could induce the apoptosis of pulmonary vascular smooth muscle cell and inhibit its proliferation well. The apoptosis ratios of pulmonary arterial vascular smooth muscle cell in simvastatin group were higher than those of other groups（ P〈 0. 01 ） , but the proliferation ratios of pulmonary arterial vascular smooth muscle cell in simvastatin group were higher than those of other groups（ P〈0.01 ）, Conclusion Simvastatin can intervent PH induced by high pulmonary blood flow well and the apoptosis of pulmonary vascular smooth muscle cell and inhibit its proliferation.

关 键 词：辛伐他汀 高肺血流 肺动脉高压 机制 

分 类 号：R725.4[医药卫生—儿科]