L-精氨酸对婴幼儿室间隔缺损修补术心肌缺血/再灌注损伤的影响  

Effects of L-Arginine on Infants Myocardial Ischemia-Reperfusion Injury during Repair of Ventricular Septal Defect

作　　者：王俊霞[1] 高金贵[2] 李浩[1] 郄娜[1] 王玲芹[1] 王会茹[1] 张丽霞[1] 

机构地区：[1]河北省儿童医院麻醉科,石家庄050031 [2]河北医科大学第二附属医院麻醉科,石家庄050000

出　　处：《实用儿科临床杂志》2007年第13期1028-1030,共3页Journal of Applied Clinical Pediatrics

基　　金：河北省科学技术研究与发展指导计划项目资助(062761181)

摘　　要：目的探讨L-精氨酸(L-Arg)加入心脏停搏液对婴幼儿心肌缺血/再灌注的影响。方法择期行室间隔缺损(VSD)修补术患儿18例,随机分为对照(C组)和L-Arg组(L组)各9例,L组停搏液中加入L-Arg5g/L(24mmol/L),C组停搏液中加入相同容积9g/L盐水。分别于诱导后(基础值,T0)、主动脉开放30min(T1)、停体外循环(CPB)6h(T2)、停CPB24h(T3)抽取动脉血,测血浆心肌肌钙蛋白I(cTnI)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,记录观察指标。结果二组血浆cTnI、MDA水平及SOD活性同时点比较差异无统计学意义(P>0.05)。二组观察指标差异无统计学意义(P>0.05)。结论含5g/LL-Arg的心脏停搏液对婴幼儿心肌缺血/再灌注损伤无影响。Objective To investigate the effects of L - arginine（ L - Arg） cardioplegic solution on infants myocardial ischemia - reperfu- sion. Met hods Eighteen patients scheduled for repair of ventricular septal defect （VSD） were randomly divided into 2 groups ： L - Arg group （ L group,n = 9） received L - Arg 5 g/L in cardioplegic solution, control group （ C group, n = 9） received saline solution in the same fashion. Blood samples were taken from artery after induction （To ） ,30 min after opening aorta（ T1 ） ,6 h after termination of C PB （T2 ） ,24 h after termination of CPB （ T3 ） for determination of the level of cTnI, MDA and SOD. Clinical parameters were observed and compared. Results The level of cTnI, MDA and SOD of 2 groups had no significant difference at the same time（ P 〉 0.05 ）. Clinical parameters have no significant difference （ P 〉0. 05 ）. Conclusion 5 g/L L - Arg cardioplegic solution has no effect on infants myocardial ischemia - reperfusion injury.

关 键 词：左旋精氨酸 婴幼儿 心肌 缺血再灌注损伤 

分 类 号：R726.5[医药卫生—儿科]