HBV标志阳性者配偶婚前紧急乙型肝炎免疫的效果  

Accelerated immunization for rapid protection against hepatitis B in the spouses of hepatitis B virus-positive subjects before marriage

作　　者：陈仕珠[1] 韩永战[1] 温风玲[1] 姚茹[1] 任雪莲[1] 

机构地区：[1]中国人民解放军第451医院感染病科,陕西省西安市710054

出　　处：《世界华人消化杂志》2007年第15期1766-1768,共3页World Chinese Journal of Digestology

摘　　要：目的:观察快速乙肝疫苗接种方案对HBV标志阳性者配偶婚前紧急乙肝免疫的效果.方法:健康受试者分为2组.组1按快程序(d0,7,14接种),组2按标准程序(mo 0,1,6接种)三角肌内接种20μg CHO乙肝疫苗.在首针接种后1,3,7,12和24 mo分别检测抗-HBs滴度等.结果:组1全程接种完成率(93.3%)显著高于组2(64.6%)(P<0.01).首针接种后1,3 mo组1血清抗-HBs阳转率(86.7%和93.3%)显著高于组2(22.9%和45.2%,P<0.01);7-24 mo各时段2组接近,无显著差异;抗-HBs有效保护率组1(77.8%,84.4%)显著高于组2(4.2%,26.2%,P<0.01);血清抗-HBs几何平均滴度(GMT)组1分别为109.5和112.8 IU/L,显著高于组2(19.6和40.1 IU/L,P<0.01).结论:d 0,7,14接种方案方便、全程接种完成率高、抗-HBs阳转率和GMT峰值高且出现早,对HBV标志阳性者配偶婚前紧急乙肝为理想的免疫方案.AIM： To evaluate the effect of accelerated immunization schedule for subjects whose spouses were HBV-positive before marriage. METHODS： Healthy subjects were divided into 2 groups. Group A contained 45 subjects while group B consisted of 48 subjects. Group A was vaccinated using the accelerated schedule （immunized on day 0, 7, 14）, and group B received the standard schedule （immunized in month 0, 1, 6）. The efficacy was detected 1, 3, 7 and 24 months after the first vaccination. RESULTS： The completion rate was significantly higher in group A than that in group B （93.3% vs 64.6%, P 〈 0,01）, The seroconversion rates （anti-HBs more than or equal to 2.1 IU/L） was significantly higher I and 3 months after the first vaccination in group A than those in group B （1 mo： 86.7% vs 22.9%, P 〈 0.01; 3 mo： 93.3% vs 45.2%, P 〈 0.01）. A higher protection rates （anti- HBs more than or equal to 10 IU/L） were found 1 and 3 month after the first dose in group A （77.8% and 84.4%） than those in the controls （4.2% and 26.2%; both P 〈 0.01）. Meanwhile, the levels of geometric titer （GMT） were also higher 1 and 3 month after the first dose in group A （109.5 and 112.8 IU/L） than those in group B （19.6 and 40.1 IU/L; both P 〈 0.01）. CONCLUSION： The accelerated schedule is simple and effective, with a higher completion rate. The seroconversion of anti-HBs and peak GMT appear earlier in the individuals immunized with the accelerated schedule, which is an ideal immunization schedule for the spouses of hepatitis B virus-positive subjects before marriage.

关 键 词：乙型病毒性肝炎疫苗 乙型肝炎病毒 快速免疫 高危人群 

分 类 号：R186[医药卫生—流行病学]