海南地区正常汉族人群对氧磷酶2基因多态性分布的研究  

Analysis on polymorphism of paraoxonase 2 gene in Chinese Hainan Han healthy nationality

作　　者：邬强[1] 钱士匀[1] 

机构地区：[1]海南医学院检验医学系,海南海口571101

出　　处：《海南医学院学报》2007年第3期201-203,207,共4页Journal of Hainan Medical University

基　　金：海南省卫生厅科研项目(2005-61)

摘　　要：目的:探讨我国海南地区汉族人群对氧磷酶2(paraoxonase 2,PON2)基因多态性(148 Ala/Gly;311 Cys/Ser)的分布情况,为进一步研究PON2关联性疾病的发病机制奠定基础。方法:应用聚合酶链反应-限制性片段长度多态性分析技术对207名我国海南地区汉族正常人进行对氧磷酶2(148 Ala/Gly及311 Cys/Ser)基因多态性的分析。结果:我国海南地区汉族正常人群对氧磷酶2基因148、311位点存在多态性,其基因频率分别为GG0.116、GA0.237、AA0.647、CC0.111、CS0.411、SS0.478;与国外其他种族人群比较,海南汉族正常人基因型频率与台湾人、苏格兰人、英格兰人、俄罗斯人、加拿大人、非裔美国人、白种美国人、澳大利亚人在不同位点上存在明显差异(P均<0.05)。结论:我国海南地区汉族正常人群对氧磷酶2基因多态性分布不同于国外其他种族,呈现明显种族、地域性差异。Objective： In order to investigate the distribution of paraoxonase 2（PON2） gene polymorphism in Chinese Hainan Han nationality and provide a basis on the study of pathogeny of diseases associated with PON2. Methods： paraoxonase 2 genepolymorphism of 207 unrelated healthy individuals in Hainan was studied by means of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results： The PON2 gene polymorphisms （148 Ala/Gly and 311 Cys/Ser） were demonstrated, the frequencies were GG0. 116, GA0. 237, AA0. 647, CC0. 111, CS0. 411, SS0. 478 respectively. In Hainan Han nationality, the frequencies of the paraoxonase 2 genotype were significantly different in someone genotype （P〈0.05） with subjects of Taiwan, Scotland, England, Russia, Canada, African American, Caucasian American, or Australia. Conclusion： These results suggest that there are significant differences in the distribution of PON2 gene between Hainan Han nationality and other ethnic population.

关 键 词：对氧磷酶2 基因 多态性 汉族 海南省 

分 类 号：Q346.5[生物学—遗传学]