生脉注射液治疗新生儿缺氧缺血性脑病53例远期随访研究  

Long-term Follow-up Study on Shengmai Injection for 53 Cases of Hypoxic Ischemic Encephalopathy in Neonates

作　　者：邱丙平[1] 邱翔彦 冯集蕴[1] 

机构地区：[1]山东省滕州市中心人民医院小儿科,滕州市杏坛路181号277500 [2]山东省滕州市工人医院

出　　处：《中医杂志》2007年第7期611-613,共3页Journal of Traditional Chinese Medicine

摘　　要：目的研究生脉注射液对新生儿缺氧缺血性脑病（HIE）的远期治疗效果。方法将106例HIE患儿随机分为两组，治疗组用生脉注射液3ml／kg加入5％葡萄糖液中静脉滴注14天，重症患儿病初每日2次，连用2～3天。对照组重症患儿用纳洛酮0．15～0．2mg加入5％葡萄糖中静脉滴注2～3天，然后改为复方丹参注射液2ml／kg加入5％葡萄糖中静脉滴注，总疗程14天。两组其他治疗相同。由专人对出院患儿填随访表，每月来院做相关检查，再次住院强化治疗。结果长期随访结果表明，治疗组在异常症状、体征、脑性瘫痪等后遗症，脑CT或MRI异常、EEG异常、第2次、3次住院方面都与对照组有显著性差异。结论生脉注射液治疗新生儿HIE，长期随访证实远期疗效也是肯定的。Objective To study the long-term therapeutic effect of Shengmai Injection for hypoxic ischemic encephalopathy （HIE） in neonates. Methods Totally 106 HIE neonates were randomly divided into two groups. Patients in treatment group were transfused with 3ml of Shengmai Injection per kilogram in 5% glucose for 14 days. For serious cases, the medication frequency could be doubled during the first 2 or 3 days. Patients in control group were transfused with 2ml of Compound Danshen Injection per kilogram in 5% glucose for 14 days. For serious cases, 0.15 to 0. 2mg of Naloxone in 5% glucose was transfused during the first 2 or 3 days. Other treatment was similar in both groups. The discharged patients were followed up monthly. Results There were obvious differences in symptoms, signs, sequela, cranial computed tomography, magnetic resonance imaging, electroencephalogram and readmission frequen- cy between two groups. Conclusion Shengmai Injection has long-term therapeutic effect on HIE in neonates.

关 键 词：生脉注射液 新生儿 缺氧缺血性脑病 随访研究 

分 类 号：R272.1[医药卫生—中医儿科学]