Study of ^(99m)Tc-TRODAT-1 Imaging on Human Brain with Children Autism by Single Photon Emission Computed Tomography  

作　　者：SUN Xiao-mian YUE Jing ZHENG Chong-xun 

机构地区：[1]Institute of Biomedical Engineering, College of Life Sciences and Technology, Xi＇an JiaoTong University（ Key Lab of Education Ministry） ,Xi＇an 710049, China [2]Department Health Child Health Care, Futian Child and Maternal Care Institute, Shenzhen 518026, China

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2007年第2期66-70,共5页中国生物医学工程学报（英文版）

摘　　要：Objective ： Evaluate the application values of ^99mTc-2 β [ N, N＇-bis （ 2-mercaptoethyl ） ethylenediamiino ] methyl, 3 β -（4-chlorophenyl） tropane （ TRODAT-1 ） dopamine transporter （DAT） SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods：Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of ^99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striaturn and cerebellum [ （ STR-BKG）/BKG ]. Results ： There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children （ P = 0. 562） and in normal controls （ P = 0. 573 ） ; dopamine transporter in brain of patients with autism increased more significantly than that in normal controls （ P = 0. 017）. Conclusion ： Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.Objective:Evaluate the application values of 99mTc-2 β[N, N′-bis(2-mercaptoethy1)ethylenediamino]methyl, 3β-(4-chlorophenyl)tropane(TRODAT-1) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods:Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum[(STR-BKG)/BKG]. Results:There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (P=0.562) and in normal controls (P=0.573); dopamine transporter in brain of patients with autism increased more significantly than that in normal controls (P=0.017).Conclusion:Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT 99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.

关 键 词：dopamine transporter children autism ^99MTC-TRODAT-1 single photonemission computed tomography 

分 类 号：R729[医药卫生—儿科]