婴幼儿血管瘤中周细胞的分布及其演变  

The distribution and evolution of pericytes in infantile hemangoma

作　　者：袁斯明[1] 姜会庆[1] 欧阳天祥[2] 邢新[3] 

机构地区：[1]南京军区南京总医院,210002 [2]上海交通大学医学院附属新华医院 [3]第二军医大学附属长海医院

出　　处：《中华整形外科杂志》2007年第4期322-324,共3页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金资助课题（30571928）　

摘　　要：目的观察婴幼儿血管瘤中周细胞的分布、表型及其演变。方法52例婴幼儿血管瘤标本,应用α-SMA作为标记抗原观察血管瘤中周细胞的分布,应用透射电镜和TUNEL染色观察周细胞的凋亡状况。结果增生早期和中期,血管瘤细胞团中有大量周细胞,周细胞与内皮细胞共同进行微血管发生;增生晚期,血管瘤周细胞大量凋亡;消退早期,微血管周围有少数周细胞;此后微血管逐渐闭塞,血管瘤周细胞也逐渐消失。结论周细胞是血管瘤的主要组成细胞之一,血管瘤周细胞和内皮细胞共同进行微血管发生和发展而主导婴幼儿血管瘤的病理演变过程。Objective To investigate the distribution, phenotype and development of pericytes in infantile hemangioma. Methods Fifty-two infantile hemangioma samples were included in our study, α-SMA was used as the marker antigen to observe the distribution of pericytes. Transmission electron microscope and TUNEL method were used to analyze the apoptosises of pericytes. Results In the early and middle proliferating stage, there existed many pericytes in hemangioma; Pericytes together with endothelial cells generated vasculogenesis. In the late proliferating stage, many pericytes became apoptotic. In the early involuting stage, there were only a few of peficytes around the micovessels; After that, the microvessels became obstruction progressively and peficytes disappeared finally. Conclusions The pericyte is one of the major constitutive cells of hemangioma. The vasculogenesis, development and disappearance of microvessels undertaken by pericytes and endothelial cells lead to the pathologic evolution of infantile hemangioma.

关 键 词：血管瘤 周细胞 内皮细胞 微血管发生 

分 类 号：R686[医药卫生—骨科学]