6-巯基嘌呤在多壁碳纳米管修饰玻碳电极上的电化学行为及其分析应用  

Electrochemical Behavior of 6-Mercaptopurine at Multiwall Carbon Nanotube Modified Glassy Carbon Electrode and Its Analytical Application

作　　者：赵军丽[1] 陈艳玲[1] 李秀丽[1] 舒菲菲[1] 

机构地区：[1]中国地质大学材料科学与化学工程学院,武汉430074

出　　处：《理化检验（化学分册）》2007年第7期540-543,546,共5页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

摘　　要：将固体多壁碳纳米管置于10g·L^-1六偏磷酸钠溶液中，通过超声搅拌制成均匀分散的悬浮液。取此悬浮液10μL，滴加于经抛光的玻碳电极的表面，在红外灯下烘干后即制成多壁碳纳米管修饰的玻碳电极（CNT／GCE）。在pH7．0的磷酸盐缓冲介质中，6-巯基嘌呤（6-MP）在0．357V（vs．Ag／AgCl）处出现一灵敏的氧化峰，其峰电流（Ip）与6-MP浓度在5×10^-7～1×10^-4mol．L^-1之间呈线性关系，检出限为5．0×10^-8mol．L^-1。应用此方法测定了3个模拟血清样品中6-MP含量，并测得方法的回收率在98．0％～104．7％之间。在6-MP浓度水平为1×10^-5mol．L^-1的条件下，测得方法的RSD（n=10）为4．2％。The multi-wall carbon nanotube （MWCNT） modified glassy carbon electrode was prepared by dropping 10 μL of homogeneously dispersed suspension of MWCNT in 10 g · L^-1 sodium hexa-metaphosphate solution on the polished surface of a glassy carbon electrode and then it was dried under radiation of IR-lamp. In a phosphate buffer of pH 7. 0, a sensitive oxidation peak given by 6-mercaptopurine （6-MP） was observed at 0. 357 V （vs. Ag/AgCl） at the above mentioned modified electrode （CNT/GCE）. Linear relationship between the peak current （Ip） and the concentration of 6-MP in the range of 5 × 10^-7-1 × 10^-4 mol · L^-1 , with a detection limit of 5.0× 10^-8mol · L^-1. The proposed method was used in the determination of 6-MP in simulated samples Of blood serum with values of recovery in the range 98. 0%-104.7%. Value of RSD＇s （n= 10） found at the concentration level of 1×10^-5mol . L^-1 of 6-MP was 4. 2%.

关 键 词：多壁碳纳米管 修饰玻碳电极 6-巯基嘌呤 六偏磷酸钠 

分 类 号：O657.313[理学—分析化学]