利眠宁的二阶导数单扫描示波极谱测定及其电化学行为  

Second Derivative Single-Sweeping Oscillopolarographic Determination of Chlordiazepoxide and Its Electrochemical Behavior

作　　者：林洪[1] 李明[1] 李德良[1] 艾华林[1] 柴跃东[1] 

机构地区：[1]玉溪师范学院化学与环境科学系,玉溪653100

出　　处：《理化检验（化学分册）》2007年第7期585-587,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

摘　　要：提出了测定药物利眠宁的二阶导数单扫描示波极谱方法。在0．12mol·L^-1氨水-NH4Cl（pH10．2±0．1）的缓冲溶液中，利眠宁于-1．25V处产生一极谱还原波，二阶导数峰电流与其浓度在1．6×10^-7～2．4×10^-5mol·L^-1范围内呈线性关系（r=0．9993，n=8），检出限为2．0×10^—8mol·L^-1。测定了片剂中利眠宁的含量。测得结果与HPLC法的结果一致，其RSD值为0．56％，回收率结果在96．4％～102．1％之间，讨论了利眠宁的电化学行为。Single-sweeping oscillopolarography was applied to the determination of chlordiazepoxide. A polarographic reductive wave of chlordiazepoxide was observed at -1.25 V in an ammoniacal buffer medium of pH 10. 2 ±0. 1. Linearity was kept between the 2nd derivative of peak current （Ip″） and the concentration of chlordiazepoxide and in the range of 1.6 × 10^-7 -2.4 × 10^-5mol · L^-1 （r=0. 999 3, n=8）, with a detection limit of 2. 0 × 10^-8 mol · L^-1. In its application to the analysis of chlordiazepoxide tablets, results obtained were in consistency with the results found by HPLC. Value of RSD＇ s （n = 8） of this method was found to be 0. 56%. Recovery test was performed and results obtained were in the range of 96. 4%- 102. 1%. A study on the electrochemical behavior of chlordiazepoxide was also made and a brief discussion was given.

关 键 词：利眠宁 单扫描示波极谱法 电化学行为 

分 类 号：O657.1[理学—分析化学]