泡沫分离法与常规方法制备甘草酸粗品的比较  

Comparison between foam fractionation and conventional processing crafts for glycyrrhizic acid inclusion compound

作　　者：兰洁[1] 杨明[1] 韩丽[1] 苏艳桃[1] 陈斯玮[1] 

机构地区：[1]成都中医药大学药学院,四川成都611130

出　　处：《华西药学杂志》2007年第1期25-27,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家科技部"十五"攻关项目(批准号:2004BA721A43)

摘　　要：目的与常规甘草酸粗品制备工艺比较,评价泡沫分离技术的特点。方法采用HPLC测定甘草酸的含量,比较泡沫分离与水提酸沉法、水提醇沉法、稀氨水渗滤酸沉法、氨性乙醇提酸沉法等4种常用工艺提取的甘草酸转移率、甘草酸粗品纯度、纯度提高比、工时等。结果泡沫分离工艺所分离的甘草酸转移率为91.86%,粗品纯度为32.34%,纯度提高比为2.01。结论泡沫分离技术应用于甘草皂苷的分离有效而可行。OBJECTIVE To evaluate the characteristics of foam fraetionation in separating glyeyrrhizie glycosides by comparing with 4 conventional processing crafts. METHODS The content of glycyrrhizic acid was determined by HPLC, foam fractionation craft was compared with 4 conventional processing ones （ water - acid extraction, water - alcohol extraction, dilute ammonia water percolation, ammonia - alcohol extraction） in terms of glycyrrhizic acid transfer ratio, purity of glycyrrhizic acid inclusion compound, elevation ratio of purity, man - hour and so on. RESULTS Foam fractionation had some advantage, induding glycyrrhizic acid transfer ratio of 91.86% , glycyrrhizic purity of 32.34% , purity elevation ratio of 2.01. CONCLUSION Foam fractionation is effective and feasible in separating glycyrrhizic glycosides.

关 键 词：泡沫分离 甘草酸粗品 制备工艺 转移率 

分 类 号：R284.2[医药卫生—中药学] R927[医药卫生—中医学]