复明片对视网膜脱离复位三磷酸腺苷、丙二醛含量和超氧化物歧化酶活性的影响  

Effect of Fuming Tablet on ATP, MDA Content and SOD Activity in Retinal Tissue of Rabbit Retinal Detachment and Reattachment Model

作　　者：朱志容[1] 彭清华[2] 陈吉[2] 

机构地区：[1]中国中医科学院眼科医院,北京100040 [2]湖南中医药大学,湖南长沙410007

出　　处：《中国中医药信息杂志》2007年第8期32-34,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省教育厅科研基金资助(03B028);湖南省人民政府学位委员会优秀博士学位论文基金资助项目(湘教通[2001]164号0116);湖南省教委科研基金资助项目(98B078)

摘　　要：目的观察复明片对视网膜脱离(retinaldetachment,RD)及复位视网膜组织中三磷酸腺苷(ATP)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响。方法将48只家兔随机分为4组,每组12只,采用视网膜下腔注射透明质酸钠的方法建立RD动物模型,10～14d后视网膜自动复位。正常组、模型组给予生理盐水,西药组给予西药混合溶液,复明片组给予复明片混悬液灌胃,并于造模后1周(视网膜脱离未复位)及造模后3周(视网膜复位早期)进行各组兔视网膜组织ATP、MDA含量及SOD活性测定。结果复明片能在视网膜脱离时及复位后提高视网膜组织ATP含量及SOD活性,降低脂质过氧化产物MDA的含量,效果类似于ATP、维生素B1、维脑路通混合制剂。结论复明片能明显改善视网膜能量供应,提高视网膜抗氧化能力,减轻脂质过氧化反应,在一定程度上减轻或延缓视网膜病变的发展。Objective To observe the effect of Fuming Tablet on the content of ATP and MDA, and the activity of SOD in retinal tissue of rabbit retinal detachment （RD） and reattachment model. Methods 48 rabbits were randomly divided into 4 groups, with 12 in each. 12 rabbits were taken as healthy control and fed with normal saline, the others in model group, western medicine group and Fuming Tablet group were prepared as RD model by injecting Sodium Halyuronate （Helen） into subretinal spaces, and the detached retinas were reattached automatically in 10 - 14 days. They were administered with normal saline, mixed preparation of western medicines and Fuming Tablet suspension respectively, then the content of ATP, MDA and SOD activity were determined in postoperative 1 week （the retina remained detached） and 3 weeks （the detached retina reattached）. Results Effect of fuming tablet of increasing the content of ATP and the activity of SOD, reducing the content of MDA was similar with that of the mixed preparation of ATP, VitB1 and Venoruton. Conclusion Fuming Tablet can significantly improve the oxidation resistance and depress the lipid peroxidation of retinal tissue, thus alleviate and inhibit the development of retinal pathological changes to some extent.

关 键 词：视网膜脱离复位 复明片 三磷酸腺苷 丙二醛 超氧化物歧化酶 动物模型 

分 类 号：R285.5[医药卫生—中药学]