醛类及鞣酸对软胶囊稳定性的影响  

Study on the Effect of Aldehydes and Tannic Acid on the Stability of Soft Capsules

作　　者：许汉林[1] 黄成刚[1] 吴志明[1] 

机构地区：[1]湖北中医学院药学院,湖北武汉430061

出　　处：《中国中医药信息杂志》2007年第8期52-53,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖北省教育厅项目(2001B04004)

摘　　要：目的研究醛类及鞣酸对软胶囊崩解性能的影响,探讨改善软胶囊崩解迟缓的措施。方法向软胶囊囊材中添加醛类物质及鞣酸,进行加速稳定试验,考察其崩解性能。结果微量醛类物质的增加能显著延长软胶囊的崩解时间,不同种类的醛类物质及鞣酸对软胶囊崩解时间影响不一,加入适量有机酸(如富马酸)有助于改善软胶囊的崩解性能。结论应对软胶囊囊材原材料及内容物中的醛类及鞣酸量进行严格控制,保证软胶囊崩解时限符合药典规定。Objective To study the influence of aldehydes and tannic acid on soft capsules, approach how to prevent soft capsules from delayed disintegration. Methods Add aldehydes and tannic acid to soft capsules material ingredient, to proceed accelerating stability trial and test the disintegration time. Result Little increase of aldehydes amount had great effect on the disintegration time of soft capsules, different aldehydes and tannic acid had different effect on the disintegration time, adding some organic acid such as fumaric acid to the material would improve disintegrating property. Conclusion The amount of aldehydes and tannic acid contained in the material and ingredient should be controlled strictly when prepare soft capsules so that the disintegration time of capsules could be complying with the Pharmacopeia.

关 键 词：甲醛 软胶囊 崩解时限 富马酸 鞣酸 

分 类 号：R283.5[医药卫生—中药学]